The objective of the study was to examine the usefulness and efficiency of ultrasound-guided core needle biopsy as a diagnostic procedure. Tumors of the parotid region are in most cases benign in nature and usually belong to the parotid gland. Nevertheless, it must be taken into account that tumors in the parotid-masseteric region have outcomes in other organs or system of organs, with the clinical presentation of isolated tumor states. We prospectively and retrospectively analyzed medical records of 80 patients with the diagnosis of parotid region tumor, ages 18-80 years. Ultrasound core-needle biopsy (one surgeon) was performed by Easy Core Biopsy Device 18 gauge. The patients were examined at the Department of Maxillo-Facial Surgery, Clinical Hospital Zemun, Belgrade, Serbia. In the period from May 2008 to may 2012. 54 men and 26 women were examined. Average age was 59.80 (61.57 male, 52.96 female). 17 malignant tumors were detected (21.25%), 44 benign neoplasm (55%), and 19 non-neoplastic lesions (23.75%). Lesions were located in parotid region, cervical lymphonodes, and the cervical soft tissue. The frequencies of malignancy tumors were as follows: 6 salivary gland carcinomas (Adenocarcinomas 5, Acinic cell carcinomas, Adenoid cystic carcinoma 1, Mucoepidermoid 1), Lymphoma 6 (Hodgkin 2, Non-Hodgkin 2), Secondary depositions 6 (SCC 3, Adenocarcinoma prostatae 1, Melanoma 1). Benign neoplasm distributions were as follows: Salivary gland adenomas 21 (Pleomorph adenoma 19, Basal cell adenoma 2), Warth tumors 16, Lipoma 5, Oncocytoma 2. Non-neoplastic lesions distribution frequencies were: Cystic parotid tissue changes 5, Mucous cyst 1, Tuberculous sialadenitis 1, Sarocidosis 2, Reactive lymph node 1, Toxoplasmoses 2, Chonic sialadenitis 6, Sjögren’s syndrome 1. Ultrasound-guided core needle biopsy is a highly specific, very sensitive and accurate procedure for the diagnosis of salivary gland lesions and it can be performed as an safe outpatient procedure, alternative to classical procedures of open-surgery (e.g. salivary gland tumors extirpation).

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