The objective of the study was to examine the usefulness and efficiency of ultrasound-guided core needle biopsy as a diagnostic procedure. Tumors of the parotid region are in most cases benign in nature and usually belong to the parotid gland. Nevertheless, it must be taken into account that tumors in the parotid-masseteric region have outcomes in other organs or system of organs, with the clinical presentation of isolated tumor states. We prospectively and retrospectively analyzed medical records of 80 patients with the diagnosis of parotid region tumor, ages 18-80 years. Ultrasound core-needle biopsy (one surgeon) was performed by Easy Core Biopsy Device 18 gauge. The patients were examined at the Department of Maxillo-Facial Surgery, Clinical Hospital Zemun, Belgrade, Serbia. In the period from May 2008 to may 2012. 54 men and 26 women were examined. Average age was 59.80 (61.57 male, 52.96 female). 17 malignant tumors were detected (21.25%), 44 benign neoplasm (55%), and 19 non-neoplastic lesions (23.75%). Lesions were located in parotid region, cervical lymphonodes, and the cervical soft tissue. The frequencies of malignancy tumors were as follows: 6 salivary gland carcinomas (Adenocarcinomas 5, Acinic cell carcinomas, Adenoid cystic carcinoma 1, Mucoepidermoid 1), Lymphoma 6 (Hodgkin 2, Non-Hodgkin 2), Secondary depositions 6 (SCC 3, Adenocarcinoma prostatae 1, Melanoma 1). Benign neoplasm distributions were as follows: Salivary gland adenomas 21 (Pleomorph adenoma 19, Basal cell adenoma 2), Warth tumors 16, Lipoma 5, Oncocytoma 2. Non-neoplastic lesions distribution frequencies were: Cystic parotid tissue changes 5, Mucous cyst 1, Tuberculous sialadenitis 1, Sarocidosis 2, Reactive lymph node 1, Toxoplasmoses 2, Chonic sialadenitis 6, Sjögren’s syndrome 1. Ultrasound-guided core needle biopsy is a highly specific, very sensitive and accurate procedure for the diagnosis of salivary gland lesions and it can be performed as an safe outpatient procedure, alternative to classical procedures of open-surgery (e.g. salivary gland tumors extirpation).

Persistent infection of Human papillomavirus (HPV) is the strongest epidemiological factor associated with intraepithelial neoplasia and cervical cancer. These days, infection with Human papillomavirus is the most common type of sexually transmitted disease. In most cases, infection is asymptomatic and it remains undiagnosed. Women infected with high-risk types of the virus are at greater risk of developing severe dysplastic changes or cancer. The aim of this study was to examine the association between HPV type 16/18, cytology, colposcopy, biopsy and risk factors of developing intraepithelial lesions of low L-SIL and a high level of H-SIL. The study included 864 patients who had undergone detection of HPV type 16/18 DNA using in situ hybridization. All study participants were divided into three categories according to the presence of H-SIL, L-SIL and benign histologic findings. In the case study group that had L-SIL and H-SIL there was a significant higher percentage of HPV infection than in the group of patients with benign histologic findings. The percentage of H-SIL is highest in patients who had HR-HPV infection with types 16/18, sexual intercourse before 16 the age and two to five sexual partners. This study indicates that among the H-SIL intraepithelial neoplasia, there is a high presence of HR-HPV 16/18 related to the number of sexual partners and early sexual intercourse at a younger age as a statistically significant presence of these genotypes with L-SIL intraepithelial neoplasia.

There are many authors advocating this surgical procedure in cases where septoplasty alone isn`t efficient enough. We made short prospective study in which we approved joined surgical procedures for improving nasal function. Study was done with 2 groups of patients. In first group of patients (A) septoplasty alone was done, in second (group B) we done partial turbinectomy too. Preoperative there were significant difference in rhinomanometic readings between these two groups, but postoperatively there were not, which lead us to the conclusion that use of this method is justified in cases where turbinate enlargement is significant. In both groups there were significant (p<0, 01) improving in postoperative rhinomanometric results.

Fractures in the level of the ankle are among the most common fractures. A separate entity is associated fractures at the level of the ankle joint with fractures of the lower leg. The aim is to determine what the impact of certain preoperative factors [length preoperative period, the complications of surgical treatment and antibiotics] the length of postoperative hospital stays. This retrospective study included patients were treated surgically with associated fracture of the lower leg and ankle in the Department of Orthopedics and grammatology KBC Zemun between 2003rd by 2011. and were divided into three groups according to the duration of preoperative hospital stay. The length of postoperative hospital stay significantly affect the time to completion of the operation (ρ = 0.405, p <0.01) for the occurrence of complications (ρ = 0.465, p <0.01) and duration of antibiotic use (ρ = 0.580, p <0, 01). The average length of hospital stay in patients with complications was 19 registered (Med 18) days, whereas in patients without complications 10 registered (Med 9) days. There was a statistically significant difference in the length of hospital recovery compared to various complications (log rank = 35.74, DF = 5, p <0, 01). It is these fractures that previously disposed of as such a treatment leads to less frequent complications, a shorter stay in hospital patients and therefore lower costs of the treatment.

The discovery of Helicobacter pylori (Hp) bacteria and causal relationship of Helicobacter pylori infection with the origin of chronic gastritis, stomach and duodenal ulcer and stomach cancer represents an epochal event of the new age. The goal of the study is to examine the incidence of Helicobacter pylori infection of stomach and prove the connection between Helicobacter pylori infection and stomach and duodenum diseases (non-ulcer gastropathy, stomach ulcer, and duodenal bulb ulcer and stomach cancer). The study encompassed 250 randomly selected examinees of both genders and different age categories. All the examinees were subjected to quick urease test (QUT) from antral bioptate and stomach corpus acquired by upper gastrointestinal endoscopy with standard forceps. Hp positive examinees were subjected to one of four therapy protocols for eradication of Hp. The acquired data were treated with application of descriptive statistical methods (SV, SD, Min, MAX) and analytical statistical methods (Student t test, Hi quadrat test, Kruskal-Walish test, Mann-Whitny U-test, Wilcoxon test, ANOVA variant analysis, Spearman and Pearson correlation). 250 examinees tested by quick urease test (QUT), 54% were positive and 46% were negative (p>0.05). The proportion by genders between QUT positives and QUT negatives was approximately the same (p>0.05). Non-ulcer gastropathy was a dominant finding with both QUT negatives (92.2%) and QUT positives (77%) (p<0.01). The highest rate of eradication of Helicobacter pylori infection was shown by protocols B and D (75%), then protocol A (71%) and protocol C (57.2%) (p>0.05). Quick urease test (QUT) which requires upper digestive endoscopy and biopsy of stomach epithelia samples represents a minimum of invasive diagnostics of Helicobacter pylori infection and a minimum of confirmation of eradication in our conditions. Therapeutic protocols B and D have shown the highest rate of success in eradication with our patients.

Direct antiglobulin test (Coombs test) is used for the detection of antibodies or complement components on the red cell membrane. The result of a positive DAT in voluntary blood donors is extremely rare. The aim of our case studies was to demonstrate that the positive DAT in voluntary blood donors can be the cause of disturbances during the performance of compatibility test (crossmatch), in patients with multiple erythrocyte alloantibodies. For performing DAT we used polyspecific and monospecific AHG reagents anti-IgG, anti-C3d (Seraclone®) for the method in a test tube, and the ID Liss/Coombs card anti-IgG + C3d (Diamed®) for the gel method. During the performance of the compatibility testing, for the haematological patient who has the anti-K and antiE irregular antibodies in the serum, with phenotype blood unit, the positive result was obtained at room temperature and in the indirect antiglobulin test. In further examination, the donor red cells were tested in the direct antiglobulin test. In a test tube with poliyspecific AHG reagent test result was positive, and in the LISS/Coombs gel method test result was negative. Because of discrepancies in testing, DAT was performed with monospecific AHG reagents. Only with anti-C3d monospecific AHG reagent in tube there was a positive result with donor erythrocyte. Voluntary blood donor was a man, 61 years old, who was suffering from hypertension, treated by ACE inhibitor medication. The results of blood counts and biochemistry did not indicate existence of haemolytic process. Aetiology and consequences of positive DAT in the healthy population are not yet sufficiently investigated. This requires extensive and detailed research. Accordingly, the disturbances in the selection of blood units for the recipient should be kept in mind the existence of this phenomenon.

Malignant fibrous histiocytoma is a condition involving a tumor of the bone or soft tissues. The tumor often appears in the legs or arms, but it can develop in other parts of the body. The disease is the most common soft tissue cancer that is diagnosed in older adults, and is often diagnosed in people between the ages of 50 and 70. We present a case of giant cell malignant fibrohistiocytoma of the abdominal wall. A 77 year old woman was admitted for further evaluation and treatment of tumor in the right ingvinal region of the abdominal wall. She claimed that tumor have appeared 3 mounths earlier and it was characterized by rapid growth and tenderness. NMR demonstrated expansive heterogeneous mass, 18,6x16,2cm of diameter. We performed total extirpation of the tumor. Postoperative period was uncomplicated and she was discharged from the hospitaly in good condition. Pathohystological examination confirmed malignant fibrous histiocytoma. Depending on the stage of disease and the depth of invasion by the tumor, surgical resection is the treatment of choice. Radiotherapy, chemotherapy, and immunotherapy are other therapeutic modalities. Long term followup with regular chest X-rays and CT scans of the abdomen to detect tumor recurrence, metastasis and any lymph node involvement are mandatory.

Increased number of patients with malignant disease as the cause of death requires a specific concept in the treatment and care those patients. The concept was launched in the UK today is important for patients in the terminal stage by a comprehensive approach to palliative care. Care for these patients is specific with regard of therapy, care and psychological support to patients and their family. Palliative care, effective and quality is reflected in the best possible provided techniques to improve the quality of life in patients in the terminal stage. Marked weakness, difficult movement or immobility, pains, nausea and vomiting, constipation, and decreased food intake of fluids, are just some problems which struggle patients, so that palliative care can be influenced to a greater conforms more dignified person. Patients in the terminal stage with the liver insufficiency and associated complications are the most complex with regard of palliative care. In this paper will demonstrate the principles of palliative care patients suffering from malignant disease in Gastroenterohepatology.

Meningiomi su sporo rastući intrakranijalni ekstracerebralni ekspanzivni procesi koji nastaju od arahnoidalnih ćelija. Često su neurološki mirni, psihijatrijski se manifestuju dok ne postignu velike razmere. Depresija može postojati kao komorbiditet ili komplikacija kod pacijenata sa meningiomima. Mnoge karakteristike meningioma-veličina tumora, lokalizacija, histopatologija su istraživani u vezi sa njihovim mogućim uticajima na depresiju. Dalja istraživanja povezana sa deficitom znanja u ovim oblastima bi trebalo da donesu benefit pacijentima sa ovom vrstom intrakranijalnih tumora. Cilj ovog rada je da poboljša znanja u ovoj oblasti kod pacijenata sa ovim dijagnozama.