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KONTINUIraNa MEdICINsKa EdUKaCIja Potencijal primene matičnih ćelija kod lečenja kardiovaskularnih bolesti i kongenitalnih anomalija

Amira Fazlagic ,
Amira Fazlagic
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Miroslava Gojnic
Miroslava Gojnic
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Published: 01.12.2010.

Biochemistry

Volume 27, Issue 1 (2011)

pp. 267-269;

https://doi.org/10.5937/matmed1101267f

Abstract

Funkcionalna definicija matične ćelije podrazumeva da je to najmladja ćelija ljudskog organizma koja poseduje izvanredan kapacitet samoobnavljanja i sposobnost diferenciranja u specijalizovane tipove ćelija. Osnovna podela je na embrionalne matične ćelije i adultne matične ćelije. Embrionalne matične ćelije predstavljaju najmladje ćelije ljudskog organizma. One su pluripotentne i imaju sposobnost da se pretvore u otprilike 220 vrsta ektoderma, mezoderma i endoderma. Adultne matične ćelije su nediferentovane ćelije koje se pojavljuju u odraslom tkivu.. I one imaju sposobnost da se samoobnavljaju i proizvode diferentovane potomke, ali su one multipotentne i kapacitet diferentovanja im je ograničen. Njihova osnovna funkcija je obnavljanje oštećenog tkiva. Obzirom da kardiovaskularna oboljenja predstavljaju jedan od najčešćih uzroka morbiditeta i mortaliteta čitavog čovečanstva, interesovanje za korišćenje matičnih ćelija kod kardioloških oboljenja je u žiži interesovanja naučnika.

Keywords

stem cells,

embrional stem cells,

adult stem cells,

Cd133+,

umbilical cord blood,

bioengineering,

tissue engineering,

regenerative medicine,

cardiovascular diseases

References

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