Pacijenti sa kolorektalnim tumorima pokazivali su u visokom procentu slučajeva povišene preoperativne vrednosti tumorskih markera CEa i Ca. :19–19.
2.
Tokom operacija kolorektalnog karcinoma prosečno je disekovano 14,62 limfne žlezde po pacijentu, od čega je prosečno 2,59 limfne žlezde bilo metastatski promenjeno. 45% pacijenata je imalo metastaze u limfnih žlezdama.
3.
Postoji statistički značajna povezanosti između preoperativnih vrednosti tumorskih markera CEa i Ca 19-9 i stadijuma bolesti izražene kroz dukesovu klasifikaciju. U C2 stadijumu, gde postoji više od 4 metastatski promenjena limfna nodusa, dolazi do visokog skoka vrednosti CEa i Ca. :19–19.
4.
Metastatka zahvaćenost limfnih nodusa je statistički značajno povezana sa preoperativnim vrednostima CEa, dok preoperativne vrednosti Ca 19-9 nisu u statistički značajnoj korelaciji sa brojem metastatski promenjenih limfnih nodusa. Literatura.
5.
Nozoe T, Mori T, Okuyama E, Takahashi T, I. Increase in both CEa and Ca19-9 in sera is an independent prognostic indicator in colorectal carcinoma. j surg Oncol. 2006;(2):132–7.
6.
Eche N, Pichon M, Quillien V, Gory-Delabaere G. Basuyau jP et al. standards, options and recommendations for tumor markers in colorectal cancer. Bull Cancer. 2001;(12):1177–206.
7.
Yamamoto H, Miyake Y, Noura S, Ogawa M, Yasui M, Ikenaga M. Tumor markers for colorectal cancer. Gan To Kagaku ryoho. 2001;(9):1299–305.
8.
Chen C, Yang Sh L, Jk, Lin T, Ws C, Jiang Jk. Is it reasonable to add preoperative serum level of CEa and Ca19-9 to staging for colorectal cancer? j surg res. 2005;(2):169–74.
9.
Gebauer G, Miјller-Ruchholtz W. Tumor marker concentrations in normal and malignant tissues of colorectal cancer patients and their prognostic relevance. anticancer res. 1997;(4a):2731–4.
10.
Gold P, Goldenberg N. The Carcinoembryonic antigen ( CEa): Past, Present and Future. McGill journal of Medicine. 1997;46–66.
11.
Takano S, Kato J, Yamamoto H, Nasu, Kawamoto H. Identification of risk factors for lymph node metastasis of colorectal cancer. Hepatogastroenterology. 2007;(75):746–50.
12.
Wang Jy, Lu C, Ks C, Cj M, Wu Dc, Tsai H. Prognostic significance of pre-and postoperative serum carcinoembryonic antigen levels in patients with colorectal cancer. Eur surg res. 2007;(4):245–50.
13.
Ws W, Jk L, Tj C, Liu Jh F, Fs, Yen C. Ca19-9 as the most significant prognostic indicator of metastatic colorectal cancer. Hepatogastroenterology. 2002;(43):160–4.
14.
Holubec L Jr, Topolcan O, Pikner R. The significance of CEa, Ca 19-9 and Ca 72-4 in the detection of colorectal carcinoma recurrence. anticancer res. 2000;5237–44.
15.
Reiter W, Reuter P, C. Multivariate analysis of the prognostic value of CEa and Ca 19-9 serum levels in colorectal cancer. anticancer res. 2000;(6 d):5195–8.
16.
Wiratkapun S, Kraemer M, Scow-Choen F. High preoperative serum carcinoembryonic antigen predicts metastatic recurrence in potentially curative colonic cancer: results of a five-year study. dis Colon rectum. 2001;(2):231–5.
17.
Locker G, Harris H, Kemeny N, Macdonald Js. asCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. Clin Oncol. 2006;(33):5313–27.
18.
Liska V, Holubec L Jr, Treska V, Kormunda S. dynamics of serum levels of tumour markers and prognosis of recurrence and survival after liver surgery for colorectal liver metastases. anticancer res. 2007;(4C):2861–4.
19.
Louhimo J, Carpelan-Holmstrm M, Hj H.
20.
Ca 72-4 and CEa are independent prognostic factors in colorectal cancer. Int j Cancer. 2002;(6):545–8.
21.
Protic M, Adair C, Prus D, Usaj S H, Rs. Prospective randomized study comparing sentinel lymph node evaluation with standard pathologic evaluation for the staging of colon carcinoma: results from the United states Military Cancer Institute Clinical Trials Group study GI-01. ann surg. 2007;(6):846–57.
22.
Okuno K. surgical treatment for digestive cancer. Current issues -colon cancer. dig surg. 2007;(2):108–14.
23.
Gj C, Rodriguez-Bigas, Ma M, Va. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. Natl Cancer Inst. 2007;(6):433–41.
24.
Dr I, Pavlović. Kliničko-bolnički centar ¨dr dragiša Mišović¨, Klinika za hirurgiju, ul. Heroja Milana Tepića 1, 11000 Beograd.
Citation
Copyright
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
