Lymph node metastasis in patients with colorectal carcinoma is bed prognostic factor. High level of CEA and CA 19-9 tumor markers before surgery have had a high sensitivity and also is a combination of high specification, especially in late stage cases. Considering that, general attention was to proof a correlation between level of CEA and CA 19-9 tumor markers before surgery and number of nodal metastasis in these patients. Our study included 102 patients with colorectal carcinoma. We measured level of CEA and ca 19-9 tumor markers before surgery and compared it with number of dissected lymph node metastasis after surgery as same as comparing with Duke’s stage of carcinoma. Average level of CEA tumor marker before surgery was 44,59 μg/mol. Lowest rate was 0,8 μg/mol ant the higher was 551 μg/mol. Average level of CA 19-9 before surgery was 258, 8696 U/mol. Average number of dissected lymph nodes per patient was 14,62 within average 2,5895 was nodal metastasis. There is a high statistically signification between CEA and CA 19-9 tumor markers level before surgery and level of Duke’s classification stage after surgery. Number of nodal metastasis is correlated with level of CEA before surgery. Level of CA 19-9 before surgery is not statistically significant for number of nodal metastasis. During this examination we noticed a high increasing of CEA and CA 19-9 tumor marker levels before surgery in patients with C2 Duke’s stage with more than 4 lymph nodal metastasis found after surgery. In this patients level of CEA was higher 45,78 μg/ml comparing with patients in C1 Duke’s stage who have had CEA level 6,07 μg/ml. In patients with C2 Duke’s stage average value of CA 19-9 was extremely high – 71 U/ml. High level of CEA and CA19-9 is statistically significant for staging of colorectal malign disease as same as for number of nodal metastasis.
Pacijenti sa kolorektalnim tumorima pokazivali su u visokom procentu slučajeva povišene preoperativne vrednosti tumorskih markera CEa i Ca. :19–19.
2.
Tokom operacija kolorektalnog karcinoma prosečno je disekovano 14,62 limfne žlezde po pacijentu, od čega je prosečno 2,59 limfne žlezde bilo metastatski promenjeno. 45% pacijenata je imalo metastaze u limfnih žlezdama.
3.
Postoji statistički značajna povezanosti između preoperativnih vrednosti tumorskih markera CEa i Ca 19-9 i stadijuma bolesti izražene kroz dukesovu klasifikaciju. U C2 stadijumu, gde postoji više od 4 metastatski promenjena limfna nodusa, dolazi do visokog skoka vrednosti CEa i Ca. :19–19.
4.
Metastatka zahvaćenost limfnih nodusa je statistički značajno povezana sa preoperativnim vrednostima CEa, dok preoperativne vrednosti Ca 19-9 nisu u statistički značajnoj korelaciji sa brojem metastatski promenjenih limfnih nodusa. Literatura.
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Dr I, Pavlović. Kliničko-bolnički centar ¨dr dragiša Mišović¨, Klinika za hirurgiju, ul. Heroja Milana Tepića 1, 11000 Beograd.
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