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The relationship between thyroid gland transcriptiom factor expression and epidermal growth factor receptor mutation in the lung adenocarcinoma
Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia
Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia
Institute for Cardiovascular Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia
Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia
General Hospital Sombor , Sombor , Serbia
Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia
Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad , Novi Sad , Serbia
Published: 01.04.2018.
Volume 34, Issue 1 (2018)
pp. 45-45;
Abstract
Aim: To determine the degree of correlation between TTF-1 (+) expression and EGFR mutation status in lung adenocarcinoma. Introduction: Adenocarcinoma of the lung is mainly diagnosed based on standard morphological criteria. The thyroid gland transcription factor (TTF-1) is currently the most commonly used immunohistochemical marker in the differentiation of invasive adenocarcinoma of the lung from another primary and metastatic carcinoma, has a prognostic significance and is a predictor of the EGFR mutation status. Material and Methods: This retrospective study enrolled 60 patients with histologically confirmed primary lung adenocarcinoma who underwent lung cancer surgery at Institute for lung disease Vojvodina between 2010 and 2015. Tumor specimens of these patients were investigated for TTF-1 expression and mutations in EGFR using immunohistochemistry and PCR analysis. Statistical analysis is in statistic software Statistica 12. Results: The study included 35 men and 25 women, with an average age of 61.8 ą 8.08 years. Of the 60 cases, TTF-1 ( ) expression was recorded in 52 (87%) (p <0.001), the statistical difference is not significant when comparing smoking habitsby gender, and tumor size among them. EGFR ( ) mutation status was found in 3/60 (5%) cases [egzon 21 (2) and exon 20 (1)], of which TTF-1 (+) expression was in two cases. Conclusion: There is a statistically significant difference between the TTF-1 (-) and TTF-1 (+) adenocarcinoma and a high degree of correlation between EGFR mutation status and TTF-1 (+) expression.
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