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Reliability of determination of steroid and human epidermal growth factor 2 receptors expression and tumor molecular subtypes in breast core biopsy
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Center for pathology, Clinical center of Montenegro , Podgorica , Montenegro
Published: 01.04.2018.
Volume 34, Issue 1 (2018)
pp. 43-43;
Abstract
Aim: To investigate concordance rate between the results of expression of steroid receptors, human epidermal growth factor 2 receptors (Her2) and determined molecular subtypes in surgical specimens (SS) and samples obtained by core biopsy (CB). Introduction: CB is widely accepted method in the initial diagnosis of breast cancer, but its reliability in determining the status of steroid and Her2 receptors, Ki67 index and molecular subtypes is still a matter of debate. Material and Methods: We analyzed 54 cases of invasive breast cancer, in which the expression of estrogen (ER), progesterone (PR) and Her2 receptors and Ki67 index were determined both in CB and SS. Concordance rate for ER, PR and Her2 receptors expression and molecular subtypes, between CB and SS, was calculated using k-test (p<0.001). Results: The average age of patients was 62. In SS, Luminal A subtype was most commonly diagnosed (48%), followed by: Luminal B Her2-(31%) and TNBC (13%), while Luminal B Her2 and Her2-enriched subtypes were represented by 4% each. Frequencies of molecular subtypes in CB were: Luminal A (41%), LuminalB Her2- (33%), TNBC (15%), Luminal B Her2 (7%), Her2-enriched (4%). Concordance rate for ER receptors was 93.8%(Kappa=0.936), for PR 77.5%(Kappa=0.773), for Her2 80.0%(Kappa=0.78) and for molecular subtypes 80.9%(Kappa=0.753). Conclusion: Statistical analysis showed very good agreement in terms of determined molecular subtypes and ER receptors expression and good agreement for the expression of PR and Her2 receptors. CB represents reliable method for determining the status of expression of steroid and Her2 receptors, as well as tumor molecular subtypes.
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