Paget desease can be primary cutaneus vulvar disease,or associated with noncutaneous carcinoma gastrointenstinal origin or bladder carcinoma. Immunohistochemical analysis is very helpful to determine primary origin. Immunohistochemical finding in primary vulvar cutaneus Paget desease are CK7+, EMa+, CEa+, s100, Melana-, HMB45-. Immunohistochemical finding in pagetoid rectal adenocarcinoma are CK7-, CK20+, CEa+. Immunohistochemical finding in pagetoid transitional cell carcinoma are CK. CK. 2012;
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