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Volume 39, Issue 2, 2025
Online ISSN: 3042-3511
ISSN: 3042-3503
Volume 39 , Issue 2, (2025)
Published: 12.11.2025.
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Contents
01.12.2012.
Review Article
Malignant giant cell type fibrohistiocitom of the abdominal wall
Malignant fibrous histiocytoma is a condition involving a tumor of the bone or soft tissues. The tumor often appears in the legs or arms, but it can develop in other parts of the body. The disease is the most common soft tissue cancer that is diagnosed in older adults, and is often diagnosed in people between the ages of 50 and 70. We present a case of giant cell malignant fibrohistiocytoma of the abdominal wall. A 77 year old woman was admitted for further evaluation and treatment of tumor in the right ingvinal region of the abdominal wall. She claimed that tumor have appeared 3 mounths earlier and it was characterized by rapid growth and tenderness. NMR demonstrated expansive heterogeneous mass, 18,6x16,2cm of diameter. We performed total extirpation of the tumor. Postoperative period was uncomplicated and she was discharged from the hospitaly in good condition. Pathohystological examination confirmed malignant fibrous histiocytoma. Depending on the stage of disease and the depth of invasion by the tumor, surgical resection is the treatment of choice. Radiotherapy, chemotherapy, and immunotherapy are other therapeutic modalities. Long term followup with regular chest X-rays and CT scans of the abdomen to detect tumor recurrence, metastasis and any lymph node involvement are mandatory.
Nebojsa Mitrovic, Aleksandar Mitrovic
01.12.2012.
Review Article
Helicobacter pylori infection and comorbidity: Our diagnostic and therapeutic modalities
The discovery of Helicobacter pylori (Hp) bacteria and causal relationship of Helicobacter pylori infection with the origin of chronic gastritis, stomach and duodenal ulcer and stomach cancer represents an epochal event of the new age. The goal of the study is to examine the incidence of Helicobacter pylori infection of stomach and prove the connection between Helicobacter pylori infection and stomach and duodenum diseases (non-ulcer gastropathy, stomach ulcer, and duodenal bulb ulcer and stomach cancer). The study encompassed 250 randomly selected examinees of both genders and different age categories. All the examinees were subjected to quick urease test (QUT) from antral bioptate and stomach corpus acquired by upper gastrointestinal endoscopy with standard forceps. Hp positive examinees were subjected to one of four therapy protocols for eradication of Hp. The acquired data were treated with application of descriptive statistical methods (SV, SD, Min, MAX) and analytical statistical methods (Student t test, Hi quadrat test, Kruskal-Walish test, Mann-Whitny U-test, Wilcoxon test, ANOVA variant analysis, Spearman and Pearson correlation). 250 examinees tested by quick urease test (QUT), 54% were positive and 46% were negative (p>0.05). The proportion by genders between QUT positives and QUT negatives was approximately the same (p>0.05). Non-ulcer gastropathy was a dominant finding with both QUT negatives (92.2%) and QUT positives (77%) (p<0.01). The highest rate of eradication of Helicobacter pylori infection was shown by protocols B and D (75%), then protocol A (71%) and protocol C (57.2%) (p>0.05). Quick urease test (QUT) which requires upper digestive endoscopy and biopsy of stomach epithelia samples represents a minimum of invasive diagnostics of Helicobacter pylori infection and a minimum of confirmation of eradication in our conditions. Therapeutic protocols B and D have shown the highest rate of success in eradication with our patients.
Sabir Sagdati, Srbislava Milinic, Predrag Dugalic
01.12.2012.
Review Article
The duration of the postoperative period in patients with associated fractures of the lower leg and ankle
Fractures in the level of the ankle are among the most common fractures. A separate entity is associated fractures at the level of the ankle joint with fractures of the lower leg. The aim is to determine what the impact of certain preoperative factors [length preoperative period, the complications of surgical treatment and antibiotics] the length of postoperative hospital stays. This retrospective study included patients were treated surgically with associated fracture of the lower leg and ankle in the Department of Orthopedics and grammatology KBC Zemun between 2003rd by 2011. and were divided into three groups according to the duration of preoperative hospital stay. The length of postoperative hospital stay significantly affect the time to completion of the operation (ρ = 0.405, p <0.01) for the occurrence of complications (ρ = 0.465, p <0.01) and duration of antibiotic use (ρ = 0.580, p <0, 01). The average length of hospital stay in patients with complications was 19 registered (Med 18) days, whereas in patients without complications 10 registered (Med 9) days. There was a statistically significant difference in the length of hospital recovery compared to various complications (log rank = 35.74, DF = 5, p <0, 01). It is these fractures that previously disposed of as such a treatment leads to less frequent complications, a shorter stay in hospital patients and therefore lower costs of the treatment.
Branislav Vracevic, Dejan Ristic, Nebojsa Jovanovic, Aleksandar Stankovic, Biljana Stankovic, Voja Cvetkovic, Aleksandar Vojvodic, Zoran Rosic, Edin Redzepagic, Marko Zunic
01.12.2012.
Review Article
Taking, processing sampling and evaluation of the adequacy of the samples in lung cytopathology
The conventional cytology has a longstanding role in the diagnostics of primary and metastatic lung carcinoma. Multiple factors have influence on the choice of technique used: for example, the location of the lesion, its size, interpretation of the radiological imaging, the seriousness of the symptoms, as well as the manual skill and commitment of the physician to certain technique. In this paper, the most important sampling techniques and sample processing are shown as the most important factors of a successful pathohistological analysis.
Milosav Kiurski
01.12.2012.
Review Article
Recurrences in nonseminomatous germ cell testicular tumors with no viable cancer at postchemotherapy retroperitoneal lymphadenectomy
This sudy is performed to determine disease related outcome in metastatic nonseminomatous germ cell testicular tumors (NSGCTTs) in patients with absence of viable cancer (VC) in the postchemotherapy retroperitoneal lymphadenectomy (PC-RPLA) specimen and determine wheter clinical variables can help predict disease progression Among a survey of 163 patients submitted to PC-RPLA from 1980-2005, 126 patients (77%) had no VC (44 fibrosis, 82 teratoma). At mean follow-up (MFU) of 158+/-77.7months, 20 patients (16%) developed recurrences within median free interval of 19.3 montha, with complete response (CR) following applied therapy in 9 patients (45%). Eleven patients (8%) diead (8 of disease, 3 of' other causes). Predictors for poorer recurrence free survival (RFS) were advanced clinical stage (CS) (P<0.016), intermediate/ poor IGCCCG group (p<0.004), and PC-RPLA nodal size (p<0.0007), while for disease-speciphic survival (DSS) included recurrences (p<0.0001), PC RP residual mass (RM) diameter ((p<0.006), worse IGCCCG risk (p<0.0003) and increased HCG at PC-RPLA (p<0.0001). A subset analysis of potential predictors of poorer RFS in patients with fibrosis identified only worse IGCCCG risk (p=0.05), whereas in teratoma were worse IGCCCG risk classification (p=0.01), PC RP RM size (p<0.0005) and unfavorable histology (teratoma with malignant transformation [TT] vs. mature teratoma [MT]/immature teratoma [IMT]Xp<0.0001). Adverse impact on DSS in fibrosis had elevated HCG on PC-RPLA (p<0.013) and in teratoma the presence of unfavorable IGCCCG risk (p<0.0001), worse RP histology (p<0.05) and postoperative recurrence (p<0.0001). The 5-year DSS and RFS rates for all patients with no VC at PC-RPLA were 87% and 85%, while at 10-year were 79% and 75%, respectively (Log rank=13.155; p<0.003). Patients with no VC at PC-RPLA remain at risk of recurrence. Several clinical variables, including CS, intermediate/poor IGCCCG group, preoperative HCG level, diameter of RP RM and postoperative recurrence help better to define which patients are at risk of disease recurrence and survival; as such these patients should be followed regularly in the postoperative period.
Djordje Argirovic, Aleksandar Argirovic
01.12.2012.
Review Article
ID microgel cards in detection of IgA deficiency in patients with gastrointestinal tumors
Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency.
IgAD is characterized by apscence or very low level of serum IgA (<0.7 mg/dL) and normal serum ranges of IgG and IgM. Pathogenesis of IgAD and its molecular and genetic basis is important, knowing that this immunodeficiency is related with epithelial malignancies such as respiratory and gastrointestinal tumors. Aim of this study was to investigate IgAD in patients with gastrointestinal malignancies, as well as to determine potential relation between IgAD and certan type of tumor. The research included 60 patients with confirmed gastrointestinal tumors of various types. For every patient qualitatively were tested levels of serum IgA and anti IgA atibodies, using ID microgel cards (Particle Gel Immuno Assay methods). Levels of serum IgA were also quantitavely tested in reference laboratory. Using Particle Gel Immunoassay method, there was no evidence for decrease of serum IgA or presence of anti-IgA antibodies in our group of patinets. This result was confirmed with quantitative laboratory investigation. This study shows no significant relation between IgAD and gastrointestinal tumors, which is in accordance with actual litarture.
There have only been registered sporadic cases of carcinoma in these patients, which implies that the research should include a larger number of patients.
Also, more detail cognition of molecular and genetic mechanism of IgAD would help in understanding oncogenic effect of this immunodeficiency.
Vesna Libek, Ljiljana Sofronic-Milosavljevic, Andrijana Kulic, Ana Strugar, Ivana Simic, Jelena Djurdjevic, Ivana Gojkovic, Milena Milicev
01.12.2012.
Review Article
Histological characteristics of pulmonary langerhans cell histiocytosis
Aneurysm is defined as localized arterial dilatation by at least 50% of normal diameter. Abdominal aortic aneurysm (AAA) affects most often male patients, smokers, older than 65 years, and is considered 13th most common cause of death in the USA. Statistics is not very well developed in Serbia due to poor connection of the medical facilities that deal with this problem. Abdominal aortic aneurysm can be asymptomatic for a long period of time, and often her existence can be diagnosed only when it ruptures, which has a mortality rate of more than 90%. This paper shows a male patient, 83 years old, who is admittedto KBC Zemun with symptoms of weakness, exhaustion and anamnestic information that he had a loss of consciousness carlier that day. By means of physical examination and modern diagnostic tools a ruptured abdominal aortic aneurysm has been diagnosed. The patient has been immediately transferred to an OR where he has been urgently prepared for the operation by two anesthesiologists and then surgery has been performed in general anesthesia by all up-to-date protocols. Postoperative recovery period was satisfactory, and the patient was released from hospital in good general condition.
The importance of this paper is in the fact that there is a need for in-hospital protocols for hospitals that do not routinely work with emergency vascular pathology, in order to improve communication among admission ward and other departments (before others with anesthesia dept.) and quicken the path from diagnostic to operation room, where at this moment a lot of valuable time is lost.
Vladlmir Gogic, Vladimir Jankovic, Ivana Fajertag, Aleksandra Aleksic
01.12.2012.
Review Article
Correlation of arteriovenous stula ow and hemodialysis adequacy
The aim of our study was to determine whether there is a relationship of flow through arteriovenous fistula and adequacy of dialysis in patients treated with repeated hemodialysis. The study included 37 patients who were on the program of repeated hemodialysis for more than three months. Patients were divided into two groups according to the flow through the arteriovenous fistula. For each patient, the observed parameters were recorded at baseline and after six months. In both phases of the study, more patients who had reduced flow through the fistula had inadequate dialysis but none of these differences reached statistical significance. The frequency of abnormal values of laboratory parameters was higher in patients who had reduced flow through the fistula, but these differences were not significant in the first phase of the study. Between the two phases of the study in patients with adequate flow through the fistula, there was a reduction in the frequency of pathological values of laboratory parameters, and in the group of the patients with reduced flow rate the frequences remained the same or increased, so that in the second phase of the study the incidence of hypocalcemia was significantly higher in patients with low flow. Satisfactory flow through the vascular access is important, but not decisive factor for good dialysis adequacy and must be viewed within the context of other clinical and laboratory parameters.
Biljana Cekovic
01.12.2012.
Review Article
Diagnosis, treatment and prevention of hypertension in children
Arterial hypertension is a major risk factor for increased morbidity and mortality from cardiovascular, cerebrovascular and renal disease, and it is shown that it has its roots in childhood. There is an obvious trend in the incidence of hypertension in the pediatric population, which follows the increase in the prevalence of obesity in this population. The de¿ nition of hypertension has undergone signi¿ cant changes over the past few decades. According to the modern de¿ nition, normal systolic and diastolic blood pressure in children above 90 percentile speci¿ c for age and gender. Given the great importance of the disease, both in medical and in the broader social context, it is necessary to establish clear diagnostic criteria and treatment protocols, and effective programs for prevention and early diagnosis of hypertension in children.
Snezana Simovic, Boris Kovacevic, Jelena Marinkovic
01.12.2012.
Review Article
Surgical treatment of hemodialysis patients after femoral neck fracture
The aim of this paper is to show our results in the treatment of femur neck fractures in patients on hemodialysis. The femur neck fractures are more common in patients on hemodialysis than in patients without chronic renal failure. From the year 2000. to 2012, in the Traumatologic center of the CHC Zemun, 12 patients in terminal renal failure with femur neck fractures, were treated. The postoperative rehabilitation, occurence of complications and survival rates were followed. The operative treatment of femur neck fractures by implantation of endoprosthesis in patients with chronic renal failure, although followed by frequent complications, gives the patient a chance to return to normal activity.
Branislav Vracevic, Dejan Ristic, Aleksandar Stankovic, Nebojsa Jovanovic, Voja Cvetkovic, Biljana Stankovic, Aleksandar Vojvodic, Zoran Rosic, Edin Redzepagic, Marko Zunic