The case of concomitant occurrence of schwannoma of the ethmoid sinus and meningothelial hyperplasia in female patient without neurofibromatosis-2 is presented. The components of Schwannoma tissue and meningothelial hyperplasia cells islets were confirmed by histopathological and immunohistochemical examinations. Transitional zones of these two different tissues macroscopically as well as microscopically were not observed. Histological and immunohistochemical findings and possible pathogenesis of this uncommon tumor combination is discussed.

Cilj istraživanja je da se ispitaju neke karakteristike seksualnog ponašanja studenata (seksualna iskustva, upražnjavanje seksualnih odnosa, broj partnera, upotreba kondoma) i da se utvrde razlike u znanju, seksualnom ponašanju i percepciji rizika za oboljevanje od polnih bolesti. Studija preseka sprovedena je u populaciji studenata Visoke zdravstvene škole strukovnih studija u Beogradu. Ispitivani uzorak činilo je 246 studenata. Korišćen je anketni upitnik preuzet iz projekta „Zdravstveno stanje, zdravstvene potrebe i korišćenje zdravstvene zaštite stanovništva Srbije” iz 2000. godine koji je dizajniran od strane SZO. Upitnik je anonimno popunjavan. Za statističku obradu podataka korišćene su metode deskriptivne i eksplorativne analize, metode ukrštenih tabela uz primenu Pirsonovog χ2 testa. Analiza je urađena u softverskom paketu SPSS 13.0. Rezultati su prikazani tabelarno. Rezultati našeg istraživanja ukazuju da studenti odlično poznaju prenos HIV infekcije seksualnim putem, dok u nešto manjem procentu poznaju verikalnu transmisiju HIV infekcije. Dosledna upotreba kondoma nađena je kod polovine muških ispitanika i 2/5 ženskih ispitanika, dok po 1/5 ispitanika oba pola nikad ne koristi kondom. Nedosledna upotreba kondoma je glavni obrazac ponašanja u studentskoj populaciji. Ako pod bezbednim seksualnim odnosom podrazumevamo seksualni odnos uz upotrebu kondoma pri svakom seksualnom odnosu, sa jednom partnerom i ne upuštanje u seksualne odnose sa nepoznatim osobama, doći ćemo do zaključka da takav odnos upražnjava samo 1/3 naših studenata, a da se 2/3 rizično ponaša jer navode da nikad (17,8%), odnosno ponekad (43,5%) koriste kondom.

We investigated whether finasteride given before transurethral vapor resection (TUVRP) treatment has an impact on intra- and postoperative bleeding. Forty-two patients with diagnosis of benign prostatic hyperplasia (BPH) who had prostate volume (PV) > 30 mL underwent TUVRP: group A (n=21) received preoperatively finasteride 5 mg per day for median time of 7 months and group B (n=21) no finasteride. Preoperative evaluation include assessment of International Prostatic Symptom score (IPSS), Quality of Life (QoL), PV, maximum flow rate (Qmax) and postvoid residual (PVR). Patients mean age was 71.4± 2.1 vs 69.8 vs ± 3.4 years, respectively. Median PV was 55.5 ±21.2 vs 57.1 ±28.8 mL, respectively. Twenty-two (52%) patients had complete retention (29% vs 76%) (p<0.001). At baseline mean IPSS, QoL, Qmax and PVR were 18.1±5.9 vs 19.8±5.04, 3.3±1.7 vs 3.3±1.7, 8.1±4.4 vs 6.9±1.6 mL/s, and 146±106.9 vs 151.6±112.1 mL, respectively. The mean operation time was 59±16.8 vs 64±19.2 min, mean volume of irrigation fluid intraoperatively was 14.1±7.01 vs 15.2±8.1 L and postoperatively 7.0±2.1 vs 8.1 ±1.3 L, respectively. Mean blood loss was 312±85.9 vs 425±68.5 mL, respectively. The mean weight of resected tissue was 31.3±5.8 vs 30.75±8.4 gr, respectively. Mean duration of postoperative irrigation was 6.1 ± 4.7 vs 6.2 ±5.1 h, respectively. Thirty-six (85.7%) patients were discharged within 12 h postoperatively and the catheter is removed on 2.0±0.5 vs 2.5 ± 0.6 days, respectively. No patients received blood transfusion postoperatively. At 3 months postoperatively IPSS was 6.7±4.2 vs 5.2 ±2.01 (p<0.001), QoL 1.1±0.9 vs 1.1±0.7, Qmax 18.1±10.3 vs 17.5±8.1 mL/s (p<0.01) and PVR 41±46.1 vs 45±51.3 mL (p<0.05). The present study failed to demonstrate that preoperative treatment of BPH with finasteride did not have significant impact of perioperative bleeding at TUVRP.

Pravilan način ishrane je važan deo zdravog stila života i kao takav treba da bude usvojen u najmlađem životnom dobu. Cilj rada je bio da se utvrde navike u ishrani studenatske populacije. Istraživanje je dizajnirano kao studija preseka u kome je učestvovalo 246 studenata Visoke zdravstvene škole strukovnih studija u Beogradu. Korišćen je anketni upitnik iz istraživanja „Zdravstveno stanje, zdravstvene potrebe i korišćenje zdravstvene zaštite stanovništva Srbije” iz 2000. godine, dizajniran od strane SZO. Za statističku obradu podataka korišćene su metode deskriptivne i eksplorativne analize, metode ukrštenih tabela uz primenu Pirsonovog χ2 testa. Analiza je urađena u softverskom paketu SPSS 13.0. Rezultati istraživanja pokazuju da svakodnevno doručkuje nešto više od polovine studenata, ruča 81,7%, a večera polovina studenata. Mleko i mlečne napitke svakodnevno konzumira po jednu šolju 2/5 ispitanika, dok je sir korišćen 1-2 puta nedeljno. Krompir kao i sve vrste mesa, riba i jaja u ishrani koriste se jednom do dva puta nedeljno. Sveže povrće svakodnevno je uzimala samo trećina studenata, a sveže voće nešto više od trećine. Oko 1/5 ispitanika svakodnevno uzima slatko pecivo i slatkiše. Samo 1/5 koristi crni ražani hleb. Kao najčešći namaz u ishrani studenti koriste margarin, majonez, maslac i kajmak. Od ukupnog broja ispitanika nikada ne razmišlja o svom zdravlju pri izboru načina ishrane 7,3% studenata, ponekad razmišlja 43,5%, često 39,8%, dok 9,3% ispitanika uvek razmišlja o svom zdravlju pri izboru načina ishrane.

Cilj ove studije je procena rezultata lečenja pacijenata sa intermedijarnim i lošim rizikom po kriterijumima “International Germ Cell Cancer Collaborative Group” (IGCCCG) metastatskih neseminomskih tumora testisa (NSTT) pomoću hemioterapije i retroperitonealne limfadenektomije (RPLA). U periodu od 1982do 2005, 82 pacijenta sa metastatskim NSTT, klasificiranih kao intermedijarna (65) i loša (17) rizična grupa po IGCCCG kriterijumima, su imali posthemioterapijsku (PH)-RPLA za srednje praćenje od 95meseci. Srednji dijametar RP rezidualne mase (RM) je iznosio 3.0 cm, 15 (18.3%) pacijenata je imalo povišene vrednosti tumorskih markera u serumu (TMS) pre PH-RPLA. Dvadeset i sedam (32.9%) pacijenata je iziskivalo administraciju hemioterapije druge linije, a kod 75 (91.5%) RP RM je kompletno resecirana. Retroperitonealna histološka analiza je pokazala prisustvo fibroze kod 20 (26%), teratoma kod 36 (42%) i vitalnog karcinoma kod 26 (32%), sa preživljavanjem u 76%, 80% i 38%, respektivno. Pacijenti podvrgnuti drugoj hemioterapijskoj liniji su imali signifikantno veću učestalost vitalnog karcinoma na PHRPLA (49% prema 24%)(P<0.001). Pacijenti sa lošim rizikom NSTT nisu imali signifikantno veću verovatnoću progresije (47% prema 55%)(P=0.5) i gori ishod (53% prema 69%)(P=0.2) nego sa intermedijarnim rizikom. Analiza pacijenata koji su primali hemioterapiju prve linije pokazuje signifikantno veću verovatnoću slobode progresije (VSP) (66% prema 41%) i bolje preživljavanje (74% prema 48%)(P<0.01) posle PH-RPLA nego oni koji su primili hemioterapiju druge linije. Konstatovano je bolje preživljavanje kod pacijenata sa prvom prema drugoj liniji hemioterapije pre PH-RPLA u pogledu nalaza na RP histologiji kod fibroze (94% prema 20%), teratoma (88% prema55%) i vitalnog karcinoma (54% prema 23%)(P<0.001). Ukupno, 5-godišnja VSP i preživljavanja su iznosili 57%(95% IP, 50%-62%) i 69%(95% IP, 61%-77%). Multivarijantna analiza je pokazala da nepotpuna resekcija (P<0.001), veličina PH RM (P=0.01) i nalaz teratoma i vitalnog karcinoma (p<0.01) na PH-RPLA predstavljaju nezavisne prediktivne faktore za recidiv bolesti. Pacijenti sa uznapredovalim NSTT imaju dug vremenski interval do progresije kada se hemioterapija kombinuje sa resekcijom RM. Naši nalazi ukazuju da odgovor tumora na hemioterapiju u kombinaciji sa kompletnom resekcijom svih RM, predstavlja garanci

Utvrditi učestalost i postojanje depresivnosti u porodici HIV pozitivnih osoba u odnosu na pol, starost, socijalne karakteristike i strukturu porodice. Retrospektivnom studijom je obuhvaćeno 124 članova porodice HIV pozitivnih osoba, koji su bili u programu rada savetovališta na Infektivnoj klinici KCS u Beogradu u toku 2010 godine.Nivo depresivnosti utvrđen Beckovom i Hamiltonovom skalom je povećan kod ženskih članova porodice, posebno majki HIV pozitivnih. Depresivni simptomi su više zastupljeni i kod nezaposlenih članova, kao i onih koji procenjuju kvalitet života kao loš, a nezadovoljni su svojim zdravstvenim stanjem.HIV infekcija je savremena bolest današnjice i povezana je sa socijalnom izolacijom i stigmatizacijom kako obolelih tako i njihovih porodica. Ovakav status porodice može da vodi u razvoj depresije što utiče na kvalitet života porodice. Ove studije su pokazale da nivo depresivnosti raste kod ženskih članova porodice koja živi sa HIV infekcijom i da socijalni status, a ne HIV status utiče na nivo depresivnosti u porodici. Preventivno delovanje u osnovi mora da ima socijalnu podršku na različitim nivoima društvene zajednice porodicama HIV pozitivnih osoba kako bi se razvoj depresije sprečio.

Lymph node metastasis in patients with colorectal carcinoma is bed prognostic factor. High level of CEA and CA 19-9 tumor markers before surgery have had a high sensitivity and also is a combination of high specification, especially in late stage cases. Considering that, general attention was to proof a correlation between level of CEA and CA 19-9 tumor markers before surgery and number of nodal metastasis in these patients. Our study included 102 patients with colorectal carcinoma. We measured level of CEA and ca 19-9 tumor markers before surgery and compared it with number of dissected lymph node metastasis after surgery as same as comparing with Duke’s stage of carcinoma. Average level of CEA tumor marker before surgery was 44,59 μg/mol. Lowest rate was 0,8 μg/mol ant the higher was 551 μg/mol. Average level of CA 19-9 before surgery was 258, 8696 U/mol. Average number of dissected lymph nodes per patient was 14,62 within average 2,5895 was nodal metastasis. There is a high statistically signification between CEA and CA 19-9 tumor markers level before surgery and level of Duke’s classification stage after surgery. Number of nodal metastasis is correlated with level of CEA before surgery. Level of CA 19-9 before surgery is not statistically significant for number of nodal metastasis. During this examination we noticed a high increasing of CEA and CA 19-9 tumor marker levels before surgery in patients with C2 Duke’s stage with more than 4 lymph nodal metastasis found after surgery. In this patients level of CEA was higher 45,78 μg/ml comparing with patients in C1 Duke’s stage who have had CEA level 6,07 μg/ml. In patients with C2 Duke’s stage average value of CA 19-9 was extremely high – 71 U/ml. High level of CEA and CA19-9 is statistically significant for staging of colorectal malign disease as same as for number of nodal metastasis.

Funkcionalna definicija matične ćelije podrazumeva da je to najmladja ćelija ljudskog organizma koja poseduje izvanredan kapacitet samoobnavljanja i sposobnost diferenciranja u specijalizovane tipove ćelija. Osnovna podela je na embrionalne matične ćelije i adultne matične ćelije. Embrionalne matične ćelije predstavljaju najmladje ćelije ljudskog organizma. One su pluripotentne i imaju sposobnost da se pretvore u otprilike 220 vrsta ektoderma, mezoderma i endoderma. Adultne matične ćelije su nediferentovane ćelije koje se pojavljuju u odraslom tkivu.. I one imaju sposobnost da se samoobnavljaju i proizvode diferentovane potomke, ali su one multipotentne i kapacitet diferentovanja im je ograničen. Njihova osnovna funkcija je obnavljanje oštećenog tkiva. Obzirom da kardiovaskularna oboljenja predstavljaju jedan od najčešćih uzroka morbiditeta i mortaliteta čitavog čovečanstva, interesovanje za korišćenje matičnih ćelija kod kardioloških oboljenja je u žiži interesovanja naučnika.

Astley Cooper has described a technique, the reposition of anterior shoulder dislocation by the frontal arm elevation, on 1825. The author’s aim was to show his own results when reposing frontal shoulder dislocation by this simple and secure technique. In the KBC Zemun emergency service, from 2003 to 2007, by this technique, 32 anterior shoulder dislocations with or without fractures of the greater tuberosity fracture, were reposed. The reposition was successful in all dislocations, and total short lasting anesthesia was used to two patients (3 dislocations). The basic advantage of this technique is that it is physiological, simple and does not demand strong physical force, and the neuron-bone complications were not recorded.

The aim of the present study is to analyse fate and survival in patients with pure testicular teratoma (PTT) according to clinical stage (CS) and applied therapy. Among a survey of 1275 patients with nonseminomatous germ cell testicular tumors (NSGCT) observed from January 1982 and June 2005, we indentified 49 (4%) patients with PTT. In CS I, 3 (15%) of 20 patients on surveillance relapsed. Complete response (CR) is achieved with chemotherapy in 1 patient and combined with postchemotherapy retroperitoneal lymphadenectomy (PC RPLA) in 2 patients (fibrosis 1, teratoma 1). Four patients managed with primary RPLA had universal survival. Among 4 patients treated initially with primary chemotherapy due to persistently elevated serum tumor markers (STMs) postorchiectomy, 1 patient died at 18 months. In CS I, 27 (96%) of 28 patients are alive and free of disease (AFD) at median follow-up (MFU) of 161.6 months. In the PC group, 1 patient with partial response (PR) is lost to follow-up at 6 months, 1 patient died of disease at 27 months. Eight patients achieved CR with induction chemotherapy, whereas only 1 patient relapsed at 24 months and is rendered free of disease with RPLA (teratoma). Twelve patients underwent PC RPLA due to PR following induction chemotherapy, combined with thoracic cytoreductive surgery in 2 patients. RP histology demonstrated the finding of fibrosis in 2, teratoma in 8, teratoma with malignant transformation in 1, and vital carcinoma in 1. The patients with fibrosis, teratoma and teratoma with malignant transformation are AFD, whereas the patient with vital carcinoma on desperation RPLA died. According to initial CS IIB, IIC and III PC surgery was indicated in 20%, 91% and 50%, relapse rate was 0%, 18% and 20%, with disease specific survival (DSS) in 100%, 90% and 100%, respectively. At MFU of 189.7 months, 19 (95%) of 20 fully available patients are AFD. Overall, 46 (94%) patients had no evidence of disease (NED) at last follow-up. These data underscore the metastatic potential of PTT. A significant proportion (32%) of patients with low-stage PTT had RP disease. Furthermore, a high proportion (36%) presented initially with advanced disease and demonstrated a considerable risk of relapse despite complete resection or favorable histologic features in the resected surgical specimen.