Trisomy 13 (Sy Patau) is a clinically severe entity. 85% of the patients do not survive beyond one year, and most children die before completing six months of age. We report a female child, 30 day old, white, the third child of a non-consanguineous couple, who presented trisomy 13. The child was born at term, from a vaginal delivery, weighing 3200 g. The second day of life the development of respiratory distress translated ino KBC Kragujevac (release list no.29623). The initial clinical examination detected shisis primariy and secunday palate, ASD, stenosis rami AP, polidactily pedis dextri, microcornea and microftalmia. After 27 days of hospitalization in KBC Kragujevac, transferred to the Institute for mother and child New Belgrade, where he died after three days of receipt. During hospitalization blood samples were taken for determination of kariotip. Parents are advised that in case of subsequent pregnancies occur in the genetic counseling of the Institute for prenatal diagnosis.

Cysts of the spleen are rare disease that affects the spleen. They are divided into primary and secondary in relation to the etiology and histopathology. We report two young patients of a boy aged 16 and a girl of 15 godina. Ultrasonography and CT of the abdomen showed a large cystic mass in the spleen unclear origin. On laparotomy for both the patient was found a large cyst that reached to the upper pole of the spleen and required total splenectomy. Histopathology showed fibrous cyst wall with areas of hyaline degeneration below which there is significant blood kongstion.Etipatogenesis and different modalities of treatment for cysts of the spleen are questionable. Although pseudocysts of the spleen are rare, they must be considered in the differential diagnosis of abdominal masses in the upper abdomen in young adolescents.

An increasing number of studies support the concept that cancer stem cells (CSCs) are responsible for initiation, growth and metastasis of malignant neoplasms. CSCs represent the population with tumor initiating potential, and possess the properties of normal stem cells, including the ability of self-renewal and perpetual proliferation, as well as the specific potential of multilineage differentiation, which underlies tumor heterogeneity. The persistence of CSCs has been considered the main culprit for tumor relapse and metastasis, since conventional oncologic protocols do not eradicate CSCs. Development of specific therapeutic strategies targeting CSCs may contribute to significant advance in cancer treatment. The crucial step in CSC targeted therapy development, as well as in subsequent efficacy validation, is the identification of specific stem cell markers, where the role of pathologist is of major significance.

The same legal regulations applied for medical doctors involved in patients treatment, also refer to doctors that do not manage therapy, but whose professional activity is essential for providing adequate diagnostics. this group of professionals include pathologists, which is proven by the actual forensic practice. In modern medicine, the role of pathologists is of extreme importance in the diagnostics of many diseases. In this paper, based on presentation of particular cases from the forensic practice and literature data, the possible forms of mistakes in the work of pathologists and their associates are shown, as well as the causes and the consequences of such mistakes, together with the characteristics of the legal procedures and the significance of adequate medicolegal expertise in these cases.

Zemun hospital, the present-day Clinical Hospital Zemun-Belgrade, was founded in 1784, is the oldest hospital in the Serbia. For over two centuries, it blazed the trial and still pioneers in the application of numerous advanced medical achievements and knowledge in this region.

Rak dojke je najčešći maligni tumor i jedan od vodećih uzroka prevremene smrti žena u Republici Srbiji. Stope razboljevanja i umiranje od raka dojke su neprestano raste u poslednjih nekoliko decenija. U više od polovine slučajeva, rak dojke je otkrivena u poodmakloj fazi. U Republici Srbiji, neinvazivni rak dojke se nalazi samo u 1% slučajeva, a procenat bolesti lokalizovane samo u grudima je 37%. Uzimajući u obzir ove podatke, potrebno je upotrebiti sve dostupne metode snimanja i relevantne medicinske specijalnosti, a sve u cilju postavljanja dijagnoze raka dojke u ranoj fazi, jer je to jedini mogući način da se potpuno izleči ova teška bolest.

Cilj ovog prikaza slučaja je da na osnovu analizirane kliničke slike i raspoloživog ciklusa lečenja istakne značaj patološkog entiteta sekundarne cervikalne mijelopatije kao posledica degenerativnih spondilotičnih promena na cervikalnim pršljenovima. Ujedno, cilj je bio da se istakne značaj hirurškog tretmana, kao metoda prvog izbora u procesu uspešnog lečenja. Mi smo analizirali sveobuhvatne podatke iz medicinske dokumentacije, rezultate neuroloških kliničkih i dijagnostičkih ispitivanja:, evocirane potencijale, rezultate lumbalne punkcije, imuno - serološke nalaze i rezultate magnetne rezonance. Pretstavljen je pacijent sa naglo nastalom i progresivno razvijenom kliničkom slikom kvadripareze, prvenstveno na donjim ekstremitetima. Sprovedenim kliničko dijagnostičkim ispitivanjem dobijeni su rezultati koji su ukazali na sekundarno nastalu cervikalnu mijelopatiju, na terenu degenerativnog procesa na cervikalnom regionu. Operativno lečenje je bio izbor i metoda lečenja koja se pokazala kao dobar izbor sa uspešnim ishodom. Krajnji ishod lečenja je bio upotpunjen adekvatnom fizikalnom rehabilitacijom. Ova prikaz slučaja predstavlja ilustraciju povoljnog ishoda hirurškog lečenja cervikalne mijelopatije na terenu degenerativnih spondilotičnih promena cervikalne kičme. To je metoda prvog izbora u poboljšavaju funkcionalnog statusa pacijenata i ujedno način da se zaustavi napredovanje patološkog procesa i neurološkog deficita pacijenata.

The three year study has objective to demonstrate the number of pediatric patients up to 15 years of age examined and treated in Department of dermatovenereology, and the distribution of the most common skin diseases of the childhood. During 2011.2012. and 2013. there has been 10210 pediatric patients examined , with their parents or guardians giving anamnestic data. Than skin, hair and nails has been inspected with bacteriological or mycological swabs examination. The total count of patients in three years has been 85371, out of it 10210 pediatric patients examined by dermatovenereologist (11,96%). The most common diseases found were verrucae vulgares (53%), dermatitis atopica (15%), acne (8%), mollusca contagiosa (8%), dermatitis allergica (7%), scabies (4%). Distribution of dermatopediatric diseases in our region corresponds to findings in europian countries, except higher count of scabies patients. Pediatric dermatology is very sensitive field of dermatology, that requires multidisciplinary tretament with pediatricians, allergologists, pulmologists, otorhynolaryngologists, psychologists.