Prostate cancer is the second most common cause of cancer mortality in men population. Multifactorial etiology, unpredictable course and outcome of the disease put survival determining factors of disease in the spotlight. One of new survival prognostic factors is Charlson Comorbidity Index – CCI. We presented basic characteristics of CCI, literature review regarding the CCI, as well as advantages and disadvantages of this index. CCI represents optimal balance between ease of use and prognostic capabilities. CCI value significantly contributes to better assessment of the long-term survival and the selection of appropriate cancer therapy.

Caecal diverticulosis is a rare cause of ileocoecal pain in western population. It represents 3.6% of all colonic diverticular disease. Signs and symptoms of this disease may mimic acute appendicitis and it is found in one in every 300 appendicectomies. Giving its low incindence the correct diagnosis is usually intraoperative. Eighty-three years old male presented to the surgical admission unit with a two days long history of pain in ileocaecal region. The pain started suddenly, it was constant and worsened on cough and excertion. He was afebrile, denied nausea and vomiting, changes in bowel movements and urination. The abdomen was not distended, it was soft and tender in low right quadrant, without organomegaly. Renal sucussion was negative. There were no signs of hernias. There were traces of normal stool on the rectal examination. Blood tests revealed an elevated total leukocyte count with granulocytosis and elevated parametrs of inflamation. A provisional diagnosis of acute appendicitis was made. Taking into consideration the atypical presentation we decided to do the multislice computed tomography (MSCT) of the abdomen. It revealed a heterogenous soft tissue mass in the area of right hemicolon infiltrating the surrounding fat tissue. The patient was operated on the same day. The procedure revealed a normal looking appendix and caecal diverticulum with an inflamed wall with localized perforation. We performed a right hemicolectomy. The postoperative course was uneventful and the patient made a full recovery. Caecal diverticulosis, although a rare disease in the westwrn world should be taken into consideration in patients with pain in right lower quadrant of the abdomen. The management of this disease should be individual, depending on patient's health status and the stage of disease in the moment of diagnosis. Management of patients with confirmed caecal diverticulitis can be conservative or surgical. Surgical treatment include diverticulectomy, ileocaecal resection and right hemicolectomy.

Retroperitoneal sarcomas are mesodermic origin and include less than 1% of all malignant tumors. The most frequent histological type of sarcoma are liposarcomas. Most commonly they are located in lower extremitetes while intraabdominal findigs are rare. Early diagnosis is quite challenging because the first symptoms occur only in advanced stages of disease. The gold standard for diagnosing is MSCT. The therapeutic approach is surgical by combining radiation therapy in case of recurrence and excision was not comletly. The chemotherapy is still controversial, and most authors consider that it is not adequate way of treatment. Seventy years old woman was admitted to the department of surgery because of the pain located in theleft half of the abdomen. It lasts for 3 monthsand in recent times became stronger and accompanied by nausea. Stooll and urin were regular . Physical examination revealed painfully formation. Velaues of blood examples were within normal range. US and MSCT of the abdomen were made before operation. MSCT showed retroperitoneal TU formation size 52x35cm. The findings were confirmed during the operation. Tumor weight was 9250g. Histopathological examination showed that it was a low-grade myxoid liposarcoma. One year after surgery, there was a recurrence. The first symptoms of abdominal liposarcoma manifests only in advanced stages of the disease. Radical surgical excision first choice in treatment. If the excsion lines could not be clear radiotherapy should be added.

The aim of this paper is to present the incidence of placental abruption and placenta previa at GAO General Hospital N. Pazar like to stress the importance of bleeding in the second trimestreu pregnancy. A retrospective study was conducted at the department of gynecology and obstetrics, ZC Novi Pazar January 2008 December 2012th As the basis of the data, the history and the findings from the protocol konzervtaivno treated surgically and we pacijenata. Analizirali incidence of bleeding compared to the total number of births, maternal age, parity and gestation. During the period of 2008-2012, there were 186 abruption (1.72 %) and 34 placenta previa (0.31%). Within a given period, there were 10778 delivery of which 220 bleeding or 2.03 %. The incidence of placenta previa and ab.placente compared to 84.5% abruption and placenta previa 15.5%. The age of pregnant women who develop bleeding: the highest percentage of bleeding at the age of 26- 31god (43.6%) than in the group of 19-25 years. 82.63 % and the lowest in the group under 18 (3.18) and above 35 years of age (11.3%). Maternal parity. primipara i 92 (41.88%), second child 49 (22.27 %) , third child i 46 (20.91%), fourth child 28 (12.72%). Gestational age at which it contacted the bleeding; 8 to 27 ng (3,645), 28-34 ng 30 (13.63 %) 0.35 to 37 ng 41 (18.64 %), and 37 ng 141 (64%). Method of delivery; caesarean 117 abruption (62%) vaginal delivery 69 (38%). Placenta previa; cesarean section 28 (82.3 %) and 6 vaginal (17.6 %). Any bleeding in the second half of pregnancy should be taken seriously. Prolong pregnancy as possible. You need to pay attention to risk factors: hypertension, gestational diabetes, smoking, previous cesarean section, and in this sense preventive effect on pregnant women.

Colorectal cancer (CRC) is an important social and medical problem. Complete recovery can be achieved only if the disease is diagnosed in the early stages, most common by screening methods. Studies have shown that screening methods reduce the incidence and mortality of colorectal cancer. The methods for colorectal screening can be divided into tests that allow the detection of cancer (fecal occult blood test and fecal DNA test) and morphological tests that allow diagnosis of cancer or adenomatous polyps (flexible sigmoidoscopy, colonoscopy, double contrast barium enema, CT colography ). In people with average risk of disease, screening begins at 50 years and performed on one of the following: fecal occult blood test (every year), flexible sigmoidoscopy (every 5 years), colonoscopy (every 10 years), double contrast barium enema (every 5 years) or CT colography (every 5 years). Colonoscopy is the preferred method, and is used as a confirmatory method, if the any other methods was positive.

Natural disaster, such as earthquakes, fires and volcanic eruptions, airline and railway accidents and shipwrecks, as a rule, are very rare, but they always have human victims. Wars are also a form of mass killings of people, but the identification of war victims requires more complex procedures. The most reliable and certain methods used for identification are fingerprints, dental analysis and DNA analysis. Secondary means of identification include a personal description, medical findings, as well as evidence and clothing found on the body. The largest contribution to the identification of the bodies was given by dentists who tried to identify victims with the teeth. Dental identification is an essential procedure that is conducted either independently or as supplement identification. Dentition in process of identifying the victims is used to compare AM (ante-mortem) and PM (post mortem) anthropological characteristics and dental procedures. Today dental identification is unavoidable process, because of its simplicity and because of the speed and economy.

Hair loss in children hospitalized for malignant diseases treatment is most visible manifestation that dramatically influences their later selfconfidence. Further, this could strongly affect possible development of psychic crisis. Scientific researches on motivational aspects of involvement for provision of non-formal categories of support to patients with malignant diseases are infrequent. Therefore, this topic should be more investigated in future. Humanitarian initiative “Kilometer of hair”, as unique philanthropic activity at territory of Serbia in year 2015, had as an aim to collect hair for preparation of wigs for children treated for malignant diseases. The main question in our study was definition of key motives for hair donation. We classified three main groups of motives. Altruism was detected as motivation in almost one-half of all interviewed subjects. Second group included almost one third of all subjects and their main motivation for hair donation was empathy. The smallest percentage of hair donors was motivated with some kind of public approval and welcome from society. We believe that further research in this area could give some directives for program planning of further improvement of social awareness for psychosocial support to children with malignant diseases.

Mucinous aenocarcinoma is one of the least common variant of prostate cancer. The prognosis of this variant of prostate cancer remains controversial. We report the case of 67-year old men with severe lower urinary tract symptoms (LUTS), bladder outlet obstruction (BOO), and sense of urinary retention. The serum level of prostate specific antigen (PSA) was 10.4ng/mL. Prostate was large (56mL), hard, lobulated, with extraprostatic extension and infiltration of surrounding structures, unsuitable for radical operative treatment. The patient demonstrated poor response to complete androgen blockade (CAB) (bilateral orchiectomy, steroidal antiandrogen) after 6 months of treatment with minimal decline of PSA (7.1ng/mL) and progressive growth of the primary tumor (110mL). The patient is submitted to antiandrogen withdrawal consisted of simultaneous addition of ketoconazole with hydrocortison substitution, resulting in normalisation of PSA (<1.0ng/mL) and diminution of prostate volume (PV) (63 mL) after 2 months, followed by adjunctive radiotherapy. Ketoconazole in reduced doses was stopped 6 months after completion of radiotherapy with PSA level < 0.002ng/mL and PV 16mL. The patient is alive with no evidence of disease more than 9 years after diagnosis of primary tumor. This case demonstrated modest hormonal sensitivity of mucinous adenocarcinoma of the prostate, whereas ketoconazole combined with radiotherapy, resulted in long term survival.

Razlike u polu su pronađene u mnogim oboljenjima srca, kod moždanog udara i tumora.Razlike u poluu depresiji kod pacijenata satumorommozga su retko istraživane. Cilj rada Cilj ovog rada je bio da se utvrdi odnos između ispoljene depresivne epizode i pola kod pacijenata sa tumorom mozga. Metode rada Podaci se sastoje od 115 pacijenata sa primarnim tumorommozga, 61 muškaraca i 54 žena. Depresija pacijenata je procenjena Hamiltonov skalom depresivnosti (HADS). Nivo depresije kod žena je bila veća u odnosu namuškarce. Nije bilo statistički značajne razlike između muške i ženske grupe, iako je depresija češća kod žena. Naši podaci su slični kao i većina rezultata iz epidemioloških studija koje pokazuju da je depresija češća kod žena.Dalje studije su potrebne da pronađu konekciju između biološkog uzroka tumora mozga i depresije. Razlike u polu pomažu nam da razumemo prirodu neuropsihijatrijskih poremećaja, koje će nam pomoći da pronađemo specifične tretmane i strategije prevencije.

Cilj rada je da pokažemo metode dijagnostike, terapiju i uspešnost lečenja infertiliteta u manjim sredinama. Retrospektivnom studijom analizirali smo dijagnostiku, terapiju i uspešnost lečenja infertiliteta u periodu od 2002-2006. godine. Pratili smo kupno 94 para sa problemom infertiliteta. Kod 30 parova problem dijagnostike i lečenja infertiliteta nije ozbiljno shvaćen, tako da su u startu bili osuđeni na neuspeh. Preostala 64 para su aktivno učestvovala u dijagnostici i lečenju tako da je studija zasnovana na njima. Analizirajući anovulaciju, odnosno stimulaciju ovulacije, kod 64 pacijentkine pratili smo: uspešnost stimulacije ovulacije, trudnoće i njihov ishod, nadzor ovulacije folikulometrijom i određivanjem progesterona 20 dc, komplikacije - hiperstimulirajući ovarijalni sindrom,prosečnu starost pacijentkinja, vrstu i trajanje infertiliteta,dužinu stimulacije, prisustvo bakterija u cervikalnom kanalu, nalaz HSG, hormonski status, ishod urađenih laparoskopija, spermogram muževa i mesto lečenja infertiliteta. Uzroci steriliteta kod ispitivanih pacijentkinja su poremećaji ovulacije, oštećenje jajovoda, bakterije u cervikalnom brisu, muški faktor, godine starosti. Poremećaji ovulacije su uzroci infertiliteta u oko 30-40% slučajeva. Stimulacijom ovulacije kod 73% pacijentkinja je došlo do trudnoće a kod 62% pacijentkinja je trudnoća završena uspešno.