Schwannomas are benign sheat tumors composed of Schwann cells, which are covering peripheral nervs. Althought schwannomas can be found in any localisation, retroperitoneal scheannomas are extremly rare. Multiple schwannomas (neurilemomas) can be part of neurofibromatosis type II, as well as schwannomatosis. Depending on tumor localization, disease symptoms differ. We present a patient with multiple spinal as well as peripheral schwannomas as a part of schwannomatosis. Patient was successfully operated in cooperation between general surgeon and neurosurgeon.

The present study was performed to establish the socioepidemiological caracteristics (mean age, male to female ratio), the prevalence of various histological types of meningiomas in the groups of primary and recidivant tumors as well as Cathepsin D immunoexpression. We analysed 50 patients with primary and recidivant intracranial and intraspinal meningiomas who underwent surgery in KBC Zemun during the year 2004, with a two years follow-up. All surgical specimen were evaluated for histologic type of tumor and representative slides were immunostained with the anti-Cathepsin D antibody. In both primary and recidivant meningioma groups the number of mitosis, as factor tumor agressivness, was counted on 10 and 20 HPF and those results were statistically analyzed. A considerable difference was found when the number of mitosis and the histologic tumor grade have been compared with the Cathepsin D immunoexpression. The result lead to conlusion that the immunopositivity of Cathepsin D decreases with higher mitosis count and higher tumor grade.

Diskus hernija je bolest međupršljenskog diska kičmenog stuba koja nastaje kao posledica prolapsa (hernijacije) i prodora želatinoznog jezgra međupršljenskog diska u međupršljenske otvore (lat. foramina intervertebrales) gde vrši pritisak na korenove spinalnih živaca, a ponekad i centralno u spinalni kanal i prostor u kome se nalaze kičmena moždina i kauda ekvina koje takođe komprimuje. Uzrok diskus hernije je često fizičko preopterećenje već postojećih oštećenja međupršljenskog diska, herniacija diska, reumatične i zapaljenjske bolesti, ali i bezuzročna koja nastaje bez uticaja ikakvih spoljnih uzroka. Simptomi diskus hernije su: jak bol, najčešće lokalizovan u leđima i udovima, iradijacija bola, ukočenost i ponekad paraliza. Lečenje je konzervativno, a kod težih slučajeva i operativno.

Maligni astrocitomi su najčešći primarni tumori mozga kod odraslih i čine 2% od ukupnog broja malignih tumora. Glioblastom multiforme (GBM ) je visoko specifičan za stariju populaciju dok je kod mlađih od 14 godina izuzetno redak. GBM je malo zastupljeniji kod muškog pola nego kod ženskog u odnosu 1,6. Ovom retrospektivnom studijom obuhvaćeno je 183 pacijenata sa dijagnozom tumora mozga, operativno lečenih na odeljenju neurohirurgije KBC Zemun. U grupi mikstnih glioma postoji veća učestalost u odnosu na ostale tumore, kao i veća zastupljenost kod muškog pola 57 (60,6%), u odnosu na žensku populaciju 37 (39,4%). U odnosu na histološki tip analizirani su slučajevi koji su operisani i reoperisani (dijagnoza potvrđena PH nalazom). Od ukupno 175 operisanih i reoperisanih 40 (23%) su astrocitomi, 35 (20%) oligodendrogliomi, 94 (53,3%) multiformni glioblastomi (mikstni gliomi), i 6 (3,3%) ependimomi. Tipična lokalizacija astrocitoma i multiformnih glioblastoma je unutar temporalnog lobusa. Oligodendrogliomi su najčešće bili smešteni u prednjoj trećini velikog mozga, sa upadljivo najčešćim zahvatanjem frontalnih regiona.

The most common tumor in the cerebellopontine angle (CPA) are vestibular schwannomas and meningiomas. The purpose of this study is to present proportional representation according to gender and age, incidence of histological type, as well as relation between tumor magnitude, clinical symptoms and prognosis. A group of 38 patients with PCA expansion were examined and treated in time interval from 2006 until 2010 at clinical-hospital center “KBC Zemun – Belgrade”. Gender proportion was 22 female (57,1%) and 16 male (42,9%). Middle-aged patients (from 30 to 60 years) were predominant in age proportion 20(52,6%). The most frequent tumor in the study was vestibular schwannoma (63,1%) followed by meningioma (31,6%). The rest were various histological type tumors like cholestatoma, plexus papilloma, glioma etc. (5,3%). Tumor magnitude proportion showed that the most of the scwanoma (over 95%) were grades III and IV (according to Koss classification). The leading admission symptoms were: deferent degrees of hearing loss, cerebellar disorders and trigeminal lesions. The analysis of postoperative results for 38 patients have shown: mortality rate of 13,2%, complete lesion of facial nerve(39,4%), partial lesion(33,3%) and (27,3%) without lesion of facial nerve. Lesions of lower group of cranial nerves (IX, X and XI) had 3 patients (9%) and pyramid deficit had 6(17,3%) patients. This study showed that typical PCA vestibular schwannoma is predominantly in female and elder population presented. Recommended treatment is surgical (total or subtotal extirpation), followed by adjuvant therapy for elder patients. The most frequent causes of lethal outcome are infections and hematomas in tumor bed. The leading neurological deficit after tumor extirpation is total or partial lesion of facial nerve.