In setting of still present Covid19 infection, the aim was the analysis of epidemiological and demographical characteristics of Covid19 positive patients that were treated in our triage centre from September until December 2021. They had positive antigen or RT-PCR test on SARS-CoV2. Randomly selected patients in our triage centre were offered to fill in an anonymous questionnaire specifically designed for this study. The questionnaire examined demographic and socio-epidemiological characteristics of these patents, and the questions were of closed type. Hospitalised patients were noted. The group of 226 patients answered questionnaire. Statistic shows 55.8% were woman. Patients older than 60 years made 53.1% of the group with average alter of 58.35 ± 16 years. Most patients were vaccinated with Sinopharm ™ vaccine (66.3%). Majority of patients had Covid19 infection for the first time, used personal protection equipment, practice proper hygiene and respected epidemiological measurements. Employed and patients in pension were almost equally distributed (43.1% employed, 45.3% in pension). Among hospitalised patients (20.5%), it was statistically significant distribution of older patients mean alter 66.8 years, and non- vaccinated patients 67.5%. Statistical analysis has shown a significance regarding the previous lung diseases and hospitalisation (p-vrednost=0,008). There was no statistical significance in vaccination status in whole group. Older people with more comorbidities are in higher risk of getting more severe form of Covid19 infection, and as such, are at a higher risk for hospitalisation. Patients that were vaccinated had a lower degree of hospitalisations, and therefore a milder form of the disease. Considering this data, we would recommend vaccination for Covid19, especially in older patients with comorbidities.

We present the case of a 70-year-old female patient who sought consultation with an otolaryngologist due to a mass protruding from the left nasal cavity. The patient reported that she had noticed the mass for the past two months, although she had experienced nasal breathing difficulties for over ten years. Upon examination, a large pink mass was observed protruding from the left nostril. Anterior rhinoscopy revealed complete obstruction of both the left and right nasal cavities by the tumor mass. Computed tomography showed that the mass entirely filled both nasal cavities and all paranasal sinuses. Surgical treatment was performed, involving endoscopic sinus surgery, which resulted in the complete removal of the mass. Histopathological analysis confirmed that the mass was a case of massive sinonasal polyposis. At the six-month follow-up, no signs of recurrence were observed. Although sinonasal polyposis is a relatively common condition in rhinologic surgery, such pronounced polyposis with prolapse of polyps through the nostril is a rare presentation that can initially mimic benign or malignant tumors of the nasal cavities.

Fractal dimension is a mathematical parameter that quantifies the complexity and irregularity of biological structures. In medical sciences, fractal analysis enables quantitative differentiation between normal and pathological tissues, as well as the detection of subtle structural alterations associated with senescence, inflammation and carcinogenesis. Integration with artificial intelligence and machine learning approaches further enhances its diagnostic potential and brings it closer to clinical practice. Despite current limitations related to methodological standardization and interpretation, accumulating evidence suggests that fractal dimension may evolve into a valuable component of digital pathology, otolaryngology and personalized medicine.

The aim of the work is to examine the relationship between the clinical and pathological characteristics of colorectal cancer and indicators of disease progression. The examined group consisted of operative biopsies of colorectal carcinoma (n=75), and the control group (n=75) consisted of biopsies of adjacent non-tumor tissue of the colon from the operative preparation submitted to the Pathology Centre of the Clinical Center of Montenegro. After routine histopathological processing, classic Hematoxylin-Eosin and immunohistochemical ABC method with anti-Ki67 antibodies were applied to the 4 μm sections. The histological grade of the tumor is significantly related to the proliferation index, while the pT status depends on the invasion of lymphatic vessels, metastases in the lymph nodes and the Astler-Coller stage. Metastases in lymph nodes are highly significantly associated with invasion of lymphatic vessels and Astler-Coller tumor stage. Distant metastases are significantly related to blood vessel invasion, perineural invasion and Astler_Coller stage. The histological grade of the tumor, lymphovascular and perineural invasion, the presence of metastases in the lymph nodes, distant metastases and the Astler-Coller stage depend on the proliferative index of the tumor cells. Ki67 expression is a good marker of colorectal cancer progression due to its high sensitivity and specificity.

Cervical cancer in Serbia is one of the leading causes of illness and death in the female population. Every year, about 1,300 women fall ill and approximately 500 lose their lives due to this disease. The importance of screening for this disease is very high, but unfortunately insufficiently known in the population. We conducted a short survey on 30 women aged 20 to 40 who filled out a pre-prepared cervical cancer screening questionnaire. The results indicate that the health awareness of the female population regarding cervical cancer screening in Serbia is very low, but there is also a clear insight into the importance of geting new informations, and we believe that this study contributes to raising awareness about cervical cancer screening, which is in line with the general trend population policy in the world, given that January 2023 was declared the month dedicated to the prevention of cervical cancer with the theme: Ending cervical cancer within a few generations”.

Electromagnetic radiation represents energy transmission through an immaterial medium through a flow of energy particles or quanta of energy. When passing through the material medium, there is an interaction with the medium through which they pass, and energy is transferred to the particles of the material medium. Ionising radiation (JZ) is electromagnetic radiation consisting of EM - --waves or particles with kinetic energy sufficient to ionise the substance they pass. During ionisation, orbital electrons are ejected from the atoms of the environment as negative ions and positive ions are formed from the rest of the particles. The ions formed in this way disturb the biochemical processes in the cells, which can lead to disturbances in their functioning and division and even to the occurrence of diseases, such as tumours. The effect of ionising radiation is reflected in the impact on proteins, lipids, carbohydrates and nucleic acids. The following can be recognised as occupational diseases: acute radiodermatitis, acute radiation sickness, acute radiation cataract, chronic radiodermatitis in case of exposure to ionising radiation for at least ten years, regular radiation cataract in case of exposure to ionising radiation for at least five years, malignant diseases and damage to the hematopoietic system. It is necessary to educate the entire population about the consequences that ionising radiation has on human health, provide complete protection to workers who work in radioactive radiation zones, apply all preventive and protective measures against the effects of ionising radiation in the workplace, and provide adequate, timely and professional assistance to all workers who were exposed to ionising radiation.

In this article, we present the case of a patient with classic signs of Barlow’s disease and discrete mass on the posterior myxomatously altered cusp that were observed on echocardiographic examination. Barlow’s disease is a degenerative disease of the mitral valve in which leaf prolapse and mitral regurgitation occur, which is a significant cause of cardiovascular mortality and morbidity. Papillary fibroelastoma of the heart is a rare benign tumor of the heart, mostly located on the valves, it is detected incidentally, but it can be the cause of transient neurological defects and ischemia of the heart due to embolization or prolapse in the coronary ostia. Differentiating degenerative mitral valve disease is important, because choice of surgical correction techniques depend on this distinction, and pathohistological analysis (classical, histochemical and immunohistochemical staining) contributes to the confirmation of the diagnosis, which is important for future outcome research.

Prostate cancer is the second most common cancer in men, and the fifth most common cause of cancer death in the world. Therapeutic options are divided on the basis of staging and accurate diagnosis. Due to the lack of randomized prospective controlled studies on the treatment of prostate cancer, no therapeutic option can be preferred, although there are some recommendations. Therapy options for intraprostatic tumor include: monitoring the course of the disease, radical prostatectomy, or radiation therapy. Radical radiotherapy is an alternative to surgical treatment in the localized form of primary prostate cancer. Radiotherapy treatment has shown good results. In case of local recurrence of the disease, the recommendations are even more scarce. We present a case of a 65-year-old patient who was treated for prostate adenocarcinoma with radical radiation therapy combined with androgen deprivation therapy for one year and then about 6 years after initial therapy he was successfully treated with adjuvant salvage brachytherapy because of local carcinoma recurrence. In addition to certain recommendations for the implementation of this therapy which we proposed in the following text, we certainly recommend a personalized medical approach in such cases.

We present a 51-year-old patient who sustained multiple brain injuries after falling from a height of 5 meters. The patient was treated conservatively with barbiturate sedation, antiedematous and other supportive therapy. He recovered well. However, fifteen days after injury control, a brain-computer tomography (CT) scan revealed a posterior cranial fossa epidural hematoma on the right side, without signs of brain compression and midline shift. Since the patient was in good condition, without complaints, and with normal neurological findings, and since de novo hematoma didn’t show signs of brain compression, he was observed for a few days and discharged from the hospital in good condition. According to the literature, and which is in our case, occipital bone fracture, antiedematous therapy, and sedation are risk factors for delayed posterior fossa epidural hematoma occurrence after traumatic brain injury, so in similar circumstances, we suggest more frequent control brain CT scans. The most common localization of the epidural hematoma is in the temporal region due to middle meningeal artery injury in temporal bone fractures. Other localizations of epidural hematomas are rare. Posterior cranial fossa epidural hematomas are exceedingly uncommon findings. Also, most epidural hematomas have an acute clinical picture, and delayed epidural hematomas are atypical. So, delayed posterior cranial fossa epidural hematomas are unique findings with an incidence of less than 0.1% of all epidural hematomas.

The aim of this seminar is to present the basic methodologies of immunocytochemical and immunohistochemical staining, prerequisites for success in their performance and the practical importance of their application in routine practice. The main difference between ICC and IHC is that IHC is performed on tissue without destroying the histological architecture and it is possible to analyze the expression of molecules in the microenvironment as well. Immunochemical staining is a powerful technique routinely used to detect, localize, and quantify (quantify) cellular macromolecules in preserved tissues. Regardless of the specific method used, the first step of this technique is always the selective binding of the primary antibody to its specific antigen. Immunohistochemistry (IHC) is a method used to determine the expression of biomarkers in tissue. It is used for research and diagnostic purposes in pathology and core branches of medicine.