The present study was performed to establish the socioepidemiological caracteristics (mean age, male to female ratio), the prevalence of various histological types of meningiomas in the groups of primary and recidivant tumors as well as Cathepsin D immunoexpression. We analysed 50 patients with primary and recidivant intracranial and intraspinal meningiomas who underwent surgery in KBC Zemun during the year 2004, with a two years follow-up. All surgical specimen were evaluated for histologic type of tumor and representative slides were immunostained with the anti-Cathepsin D antibody. In both primary and recidivant meningioma groups the number of mitosis, as factor tumor agressivness, was counted on 10 and 20 HPF and those results were statistically analyzed. A considerable difference was found when the number of mitosis and the histologic tumor grade have been compared with the Cathepsin D immunoexpression. The result lead to conlusion that the immunopositivity of Cathepsin D decreases with higher mitosis count and higher tumor grade.

The case of concomitant occurrence of schwannoma of the ethmoid sinus and meningothelial hyperplasia in female patient without neurofibromatosis-2 is presented. The components of Schwannoma tissue and meningothelial hyperplasia cells islets were confirmed by histopathological and immunohistochemical examinations. Transitional zones of these two different tissues macroscopically as well as microscopically were not observed. Histological and immunohistochemical findings and possible pathogenesis of this uncommon tumor combination is discussed.

Utvrditi učestalost i postojanje depresivnosti u porodici HIV pozitivnih osoba u odnosu na pol, starost, socijalne karakteristike i strukturu porodice. Retrospektivnom studijom je obuhvaćeno 124 članova porodice HIV pozitivnih osoba, koji su bili u programu rada savetovališta na Infektivnoj klinici KCS u Beogradu u toku 2010 godine.Nivo depresivnosti utvrđen Beckovom i Hamiltonovom skalom je povećan kod ženskih članova porodice, posebno majki HIV pozitivnih. Depresivni simptomi su više zastupljeni i kod nezaposlenih članova, kao i onih koji procenjuju kvalitet života kao loš, a nezadovoljni su svojim zdravstvenim stanjem.HIV infekcija je savremena bolest današnjice i povezana je sa socijalnom izolacijom i stigmatizacijom kako obolelih tako i njihovih porodica. Ovakav status porodice može da vodi u razvoj depresije što utiče na kvalitet života porodice. Ove studije su pokazale da nivo depresivnosti raste kod ženskih članova porodice koja živi sa HIV infekcijom i da socijalni status, a ne HIV status utiče na nivo depresivnosti u porodici. Preventivno delovanje u osnovi mora da ima socijalnu podršku na različitim nivoima društvene zajednice porodicama HIV pozitivnih osoba kako bi se razvoj depresije sprečio.