Breast cancer is a serious health problem. It is the most common cancer in women. The aim of this study was to estimate the concordance between ER, PR receptor and HER-2 immunohistochemistry assessment scores in pared CNB (core needle biopsy) and surgical specimens. Histological grade, oestrogen receptor (ER) status, progesterone receptor (PR) status, and human epidermal growth factor receptor-2 (HER2) status were evaluated in a blinded fashion in CNB and in surgical excision specimens. Absolute concordance rate between core needle biopsies and surgical specimens for histological grade was 50% with κ value (0,15) for ER 92% with κ value (0,79), PR 88% with κ value (0,73) and for HER2 96% with κ value (0,91). CNB can provide reliable information in evaluation of ER, PR and HER2 status in an invasive breast carcinoma.

Mnogi autori odnedavno dovode uvezu postojanje elemenata metaboličkog sindroma(MetSy) kod bolesnika sa subkliničkim hipotiredizmom(SH).Cilj:U ovoj studiji preseka smo prikazali elemente MetSy kod novodijagnosktikovanih bolesnica sa SH ipokušali da utvrdimo njihovu povezanost. Istraživanje je obuhvatilo 70 ispitanica, 50 ispitanica sa novootrkivenim SH, i 20 eutiroidnih kontrola. Grupa bolesnica je prema vrednostima glikemije i posle OGTT testa podeljena na dve grupe, bolesnice koje imaju SH , a bez Diabetes mellitusa tip2 (DMT2), i bolesnice koje imaju i SH i DMT2. Kalkulacije su urađene pomoću EXCEL i Med Calc (verzija 9.3.8.0) programa,i pomoću programa SPSS-verzija 17. Dobili smo sledeće rezultate: Bolesnice su značajno starije u odnosu na kontrolnu grupu, imaju više vrednosti za obim struka(OS) i BMI (Index telesne mase ), značajnoveći procenat osoba sa hipertenzijom (62%) i DMT2 (36%),od toga 14% novootkrivenih sa DMT2, dok u kontrolnoj grupi nije bilo DM. Vrednosti glukoze i HbA1c su više u grupi bolesnica u odnosu na kontrolnu grupu, a nema razlike u insulinemiji i HOMA. Očekivano su vrednosti TSH i Anti TPO-At više, a koncentracije FT4 značajno niže kod ispitanica sa SH u odnosu na kontrolnu grupu.Utvrđeno je da postoji korelacija između koncentracije glukoze i TSH u grupi bolesnica,ali ne i u kontrolnoj grupi.Prevalenca MetSy je 25 % kod kontrola i 62 % kod bolesnica. S obzirom na rezultat naše studije preporučuje se odredjivanje glikemije kod svakog bolesnika kod koga je utvrđen SH,i obrnuto,određivanje tiroidnog statusa kod osoba sa DMT2. Takođe se preporučuje lečenje SH po utvrđenim kriterijumima, jer zajedno sa MetSy imaju veći rizik za razvoj kardiovaskularnog događaja.

The aim of the study was to determine the etiology and incidence diastema median of the upper jaw, with tutins and rozajs high school. Biostatistical data collection, analysis and interpretation was conducted after specialist systematic review of 100 patients, of equal gender representation. Methodological defined parallel, divergent and convergent diastema median, measured in gingival and incisal part of the crown, using a digital vernier.In multicausal aetiology dominates heritage (37,05 %), ahead of the low attachment fibrous frenulum (14,28 %) and the discrepancies in the length of the dental arch and the size of the teeth (14,28 %). Diastema median is represented in 14 persons (14.0 %), of which at 5 females 5 (10,0 %) and 9 men (18,0 %). According to the most common form is represented parallel to the median diastema, in both sexes, more common in males (10.0 %) than females (6,0 %). The incidence of diastema median in the sample is higher than the representation of the majority of Europeans, but less than most African and Asian nations.

Prostate cancer is the second most common cause of cancer mortality in men population. Multifactorial etiology, unpredictable course and outcome of the disease put survival determining factors of disease in the spotlight. One of new survival prognostic factors is Charlson Comorbidity Index – CCI. We presented basic characteristics of CCI, literature review regarding the CCI, as well as advantages and disadvantages of this index. CCI represents optimal balance between ease of use and prognostic capabilities. CCI value significantly contributes to better assessment of the long-term survival and the selection of appropriate cancer therapy.

Tumors of the gallbladder are rare. Adenomas of the gallbladder is mostly occur as papillary or tubular. Tubular adenomas of the gallbladder occur in middleaged and old people, and it is extremely rare in children. We present 61 year old woman in whom during an ultrasound examination of the abdomen for pain that lasts a long time discovered a chronic inflammation of the gallbladder and slightly polypoid tumor of the gallbladder. Cholecystectomy was performed based on ultrasonographic findings of polyps in the gallbladder. Macroscopic and microscopic established that it is a tubular adenoma type with intestinal epithelial dysplasia, which clearly indicates that it is adenoma with reliable signs of precancer Finding intraoperative cholangiography was normal, and the postoperative course was uneventful.

Bladder carcinomas are common medical problem of modern society. They represent second most common malignancy of genito-urinary sistem. Rhabdomyosarcoma is on of most common soft tissue tumor in infants and children, arising from immature cells destined to differentiate into striated muscle cells. On the other hand, bladder rhabdomyosarcomas in the adult population are extremely rare and so far only few cases are described in literature. We present a patient in the seventh decade of life, successfully operated from a rare type of embryonic bladder rhabdomyosarcoma, botrioid subtype.

Caecal diverticulosis is a rare cause of ileocoecal pain in western population. It represents 3.6% of all colonic diverticular disease. Signs and symptoms of this disease may mimic acute appendicitis and it is found in one in every 300 appendicectomies. Giving its low incindence the correct diagnosis is usually intraoperative. Eighty-three years old male presented to the surgical admission unit with a two days long history of pain in ileocaecal region. The pain started suddenly, it was constant and worsened on cough and excertion. He was afebrile, denied nausea and vomiting, changes in bowel movements and urination. The abdomen was not distended, it was soft and tender in low right quadrant, without organomegaly. Renal sucussion was negative. There were no signs of hernias. There were traces of normal stool on the rectal examination. Blood tests revealed an elevated total leukocyte count with granulocytosis and elevated parametrs of inflamation. A provisional diagnosis of acute appendicitis was made. Taking into consideration the atypical presentation we decided to do the multislice computed tomography (MSCT) of the abdomen. It revealed a heterogenous soft tissue mass in the area of right hemicolon infiltrating the surrounding fat tissue. The patient was operated on the same day. The procedure revealed a normal looking appendix and caecal diverticulum with an inflamed wall with localized perforation. We performed a right hemicolectomy. The postoperative course was uneventful and the patient made a full recovery. Caecal diverticulosis, although a rare disease in the westwrn world should be taken into consideration in patients with pain in right lower quadrant of the abdomen. The management of this disease should be individual, depending on patient's health status and the stage of disease in the moment of diagnosis. Management of patients with confirmed caecal diverticulitis can be conservative or surgical. Surgical treatment include diverticulectomy, ileocaecal resection and right hemicolectomy.