The objective of the study was to examine the usefulness and efficiency of ultrasound-guided core needle biopsy as a diagnostic procedure. Tumors of the parotid region are in most cases benign in nature and usually belong to the parotid gland. Nevertheless, it must be taken into account that tumors in the parotid-masseteric region have outcomes in other organs or system of organs, with the clinical presentation of isolated tumor states. We prospectively and retrospectively analyzed medical records of 80 patients with the diagnosis of parotid region tumor, ages 18-80 years. Ultrasound core-needle biopsy (one surgeon) was performed by Easy Core Biopsy Device 18 gauge. The patients were examined at the Department of Maxillo-Facial Surgery, Clinical Hospital Zemun, Belgrade, Serbia. In the period from May 2008 to may 2012. 54 men and 26 women were examined. Average age was 59.80 (61.57 male, 52.96 female). 17 malignant tumors were detected (21.25%), 44 benign neoplasm (55%), and 19 non-neoplastic lesions (23.75%). Lesions were located in parotid region, cervical lymphonodes, and the cervical soft tissue. The frequencies of malignancy tumors were as follows: 6 salivary gland carcinomas (Adenocarcinomas 5, Acinic cell carcinomas, Adenoid cystic carcinoma 1, Mucoepidermoid 1), Lymphoma 6 (Hodgkin 2, Non-Hodgkin 2), Secondary depositions 6 (SCC 3, Adenocarcinoma prostatae 1, Melanoma 1). Benign neoplasm distributions were as follows: Salivary gland adenomas 21 (Pleomorph adenoma 19, Basal cell adenoma 2), Warth tumors 16, Lipoma 5, Oncocytoma 2. Non-neoplastic lesions distribution frequencies were: Cystic parotid tissue changes 5, Mucous cyst 1, Tuberculous sialadenitis 1, Sarocidosis 2, Reactive lymph node 1, Toxoplasmoses 2, Chonic sialadenitis 6, Sjögren’s syndrome 1. Ultrasound-guided core needle biopsy is a highly specific, very sensitive and accurate procedure for the diagnosis of salivary gland lesions and it can be performed as an safe outpatient procedure, alternative to classical procedures of open-surgery (e.g. salivary gland tumors extirpation).

Direct antiglobulin test (Coombs test) is used for the detection of antibodies or complement components on the red cell membrane. The result of a positive DAT in voluntary blood donors is extremely rare. The aim of our case studies was to demonstrate that the positive DAT in voluntary blood donors can be the cause of disturbances during the performance of compatibility test (crossmatch), in patients with multiple erythrocyte alloantibodies. For performing DAT we used polyspecific and monospecific AHG reagents anti-IgG, anti-C3d (Seraclone®) for the method in a test tube, and the ID Liss/Coombs card anti-IgG + C3d (Diamed®) for the gel method. During the performance of the compatibility testing, for the haematological patient who has the anti-K and antiE irregular antibodies in the serum, with phenotype blood unit, the positive result was obtained at room temperature and in the indirect antiglobulin test. In further examination, the donor red cells were tested in the direct antiglobulin test. In a test tube with poliyspecific AHG reagent test result was positive, and in the LISS/Coombs gel method test result was negative. Because of discrepancies in testing, DAT was performed with monospecific AHG reagents. Only with anti-C3d monospecific AHG reagent in tube there was a positive result with donor erythrocyte. Voluntary blood donor was a man, 61 years old, who was suffering from hypertension, treated by ACE inhibitor medication. The results of blood counts and biochemistry did not indicate existence of haemolytic process. Aetiology and consequences of positive DAT in the healthy population are not yet sufficiently investigated. This requires extensive and detailed research. Accordingly, the disturbances in the selection of blood units for the recipient should be kept in mind the existence of this phenomenon.

Persistent infection of Human papillomavirus (HPV) is the strongest epidemiological factor associated with intraepithelial neoplasia and cervical cancer. These days, infection with Human papillomavirus is the most common type of sexually transmitted disease. In most cases, infection is asymptomatic and it remains undiagnosed. Women infected with high-risk types of the virus are at greater risk of developing severe dysplastic changes or cancer. The aim of this study was to examine the association between HPV type 16/18, cytology, colposcopy, biopsy and risk factors of developing intraepithelial lesions of low L-SIL and a high level of H-SIL. The study included 864 patients who had undergone detection of HPV type 16/18 DNA using in situ hybridization. All study participants were divided into three categories according to the presence of H-SIL, L-SIL and benign histologic findings. In the case study group that had L-SIL and H-SIL there was a significant higher percentage of HPV infection than in the group of patients with benign histologic findings. The percentage of H-SIL is highest in patients who had HR-HPV infection with types 16/18, sexual intercourse before 16 the age and two to five sexual partners. This study indicates that among the H-SIL intraepithelial neoplasia, there is a high presence of HR-HPV 16/18 related to the number of sexual partners and early sexual intercourse at a younger age as a statistically significant presence of these genotypes with L-SIL intraepithelial neoplasia.

Meningiomi su sporo rastući intrakranijalni ekstracerebralni ekspanzivni procesi koji nastaju od arahnoidalnih ćelija. Često su neurološki mirni, psihijatrijski se manifestuju dok ne postignu velike razmere. Depresija može postojati kao komorbiditet ili komplikacija kod pacijenata sa meningiomima. Mnoge karakteristike meningioma-veličina tumora, lokalizacija, histopatologija su istraživani u vezi sa njihovim mogućim uticajima na depresiju. Dalja istraživanja povezana sa deficitom znanja u ovim oblastima bi trebalo da donesu benefit pacijentima sa ovom vrstom intrakranijalnih tumora. Cilj ovog rada je da poboljša znanja u ovoj oblasti kod pacijenata sa ovim dijagnozama.

The histologic finding of teratoma occures in aproximately 40% of all postchemotherapy retroperitoneal lymphadenectomy (PC-RPLA) for disseminated nonseminomatous testicular tumors (NSTT). We evaluated patients undergoing PCRPLA for teratoma to determine risk factors for recurrence and clinical outcome. Among a survey of 193 patients submitted to PC-RPLA due to metastatic NSTT from 1980-2005, we identified 82 patients (42%) who were found to have only teratoma in the retroperitoneum. Sixty-seven patients (82%) received only induction cisplatin-based chemotherapy, and 15 (18%) required 2nd line chemotherapy. PC-RPLA histology revealed mature teratoma (MT) in 86%, immature teratoma (IMT) in 12% and teratoma with malignant transformation (TMT) in 2%. Sixteen patients (19%) relapsed within median free interval of 22 months. Among 13 patients submitted to redoRPLA, discordant histology occurred in 6 patients (46%) (2 TMT, 4 viable germ cell tumors [GCT]), all with worst histology in comparison to primary RPLA. One relapsing patient with only elevated serum tumor markers (STMs) achieved complete response with chemotherapy alone. Two patients relapsed at 21 and 74 months with widespread metastasis and died despite salvage chemotherapy. Seven of 13 patients (54%) who were rendered free of disease (FOD) with redo-RPLA, relapsed again. All but one died despite salvage treatment (2 of chemotherapy related toxicity) within mean survival time (MST) of 86.7+/-26.1 (95% confidence interval [CI], 98.79- 149.21). At mean follow-up (MFU) of 135+/-62.6 months (95% CI, 98.79-149.21), alive and free of disease (AFD) are 90% patients. The probability of being reccurence-free at 5- and 10- year was 87% and 81%, respectively. The 5- and 10- year probability of disease speciphic survival (DSS) were 98% and 89%, respectively. On multivariate analysis residual mass size (p<0.005) and worse IGCCCG risk group (p=0.01) predicted disease recurrence. Patients with residual teratoma after PC-RPLA continue to exibit a 19% risk of recurrence even 10 years after RPLA, with 46% recurrence being with worse histology. These data support that these patients should undergo long-term surveillance of their retroperitoneum in the setting of a large residual mass or elevated IGCCCG classification risk.

Nonspeci¿ c interstitial pneumonia is a type of idiopathic interstitial pneumonia. By de¿ nition, the cases of nonspeci¿ c interstitial pneumonia are those which cannot be classi¿ ed as any other type of interstitial pneumonia. The Material of the investigation included 12 transbronchial biopsy lung samples. The quantity, structure and distribution of speci¿ c cellular elements were determined semiquantitatively, recognizing three levels of the lesions’ intensity: mild/ poor, moderate, and intense/abundant. The interalveolar septa were most frequently moderately thickened (50% of the cases) due to the presence of inÀ ammatory cells and multiplied connective. Of the inÀ ammatory cells, lymphocytes were most common and greatest in quantity (abundant, moderate and poor in 4, 5, and 3 cases respectively), followed by plasma cells and macrophages. The septal connective was moderately and mildly multiplied in 2 and 4 cases respectively. The lumen of the alveoli was in¿ ltrated by lymphocytes and macrophages, while poor peribronchial and perivascular lymphocyte in¿ ltrates were most commonly found. The interalveolar septa were most frequently moderately thickened due to the presence of chronic inÀ ammatory cells, predominantly lymphocytes, as well as to mildly-to-moderately multiplied connective. The lymphocytes usually permeated the septa diffusely. Bronchiolar and blood vessel ¿ ndings were nonspeci¿ c.

Increased number of patients with malignant disease as the cause of death requires a specific concept in the treatment and care those patients. The concept was launched in the UK today is important for patients in the terminal stage by a comprehensive approach to palliative care. Care for these patients is specific with regard of therapy, care and psychological support to patients and their family. Palliative care, effective and quality is reflected in the best possible provided techniques to improve the quality of life in patients in the terminal stage. Marked weakness, difficult movement or immobility, pains, nausea and vomiting, constipation, and decreased food intake of fluids, are just some problems which struggle patients, so that palliative care can be influenced to a greater conforms more dignified person. Patients in the terminal stage with the liver insufficiency and associated complications are the most complex with regard of palliative care. In this paper will demonstrate the principles of palliative care patients suffering from malignant disease in Gastroenterohepatology.

There are many authors advocating this surgical procedure in cases where septoplasty alone isn`t efficient enough. We made short prospective study in which we approved joined surgical procedures for improving nasal function. Study was done with 2 groups of patients. In first group of patients (A) septoplasty alone was done, in second (group B) we done partial turbinectomy too. Preoperative there were significant difference in rhinomanometic readings between these two groups, but postoperatively there were not, which lead us to the conclusion that use of this method is justified in cases where turbinate enlargement is significant. In both groups there were significant (p<0, 01) improving in postoperative rhinomanometric results.

LCH is characterized by the presence of Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. The investigated material included open lung biopsy samples taken from seven patients (four males and three females) at the mean age of 23.2 years. They were all smokers. The intensity of the histological lesions was semiquantitatively measured, differentiating three intensity grades: mild, moderate and intense. In most cases (3/7), the interalveolar septa were focally and intensively thickened. The inÀ ammatory in¿ ltrates in the septa were focal, intense in 3/7, moderate in 1/7, and mild in 1/7 specimens. Lymphocytes prevailed, followed by macrophages, eosinophil granulocytes, and plasma cells. The lumen of the alveoli was occupied by a few macrophages and lymphocytes, sparse plasma cells and few eosinophil granulocytes. The alveolar cells were focally cuboid in 7 cases. Histiocyte aggregates were detected in all specimens, most frequently localized peribronchiolarly (7/7) and in the intraalveolar septa (4/7). The aggregates had either a clear (15/25), or a relatively clear (10/25) demarcation line against the periphery. The aggregates were predominantly composed of Langerhans’ cells (7/7, abundant), followed by eosinophil granulocytes (abundant in 4/25, moderate in 8/25, sparse in 13/25), lymphocytes (sparse in 10/25 and moderate in 15/25 cases), and plasma cells (sparse in 10/25). The Langerhans’ cells were CD1a and S 100 positive. Histiocyte aggregates were registered in all biopsy samples; the Langerhans’ cells were CD1a and S100 positive.