Prostate cancer is the second most common cause of cancer mortality in men population. Multifactorial etiology, unpredictable course and outcome of the disease put survival determining factors of disease in the spotlight. One of new survival prognostic factors is Charlson Comorbidity Index – CCI. We presented basic characteristics of CCI, literature review regarding the CCI, as well as advantages and disadvantages of this index. CCI represents optimal balance between ease of use and prognostic capabilities. CCI value significantly contributes to better assessment of the long-term survival and the selection of appropriate cancer therapy.