Preeclampsia is a pregnancy-specific syndrome of unknown etiology and represents multisystem disorder. It is characterized by the increased blood pressure, proteinuria, and edema. Preeclampsia is a great risk for both mother and fetus. Disturbances of the balance between the production of reactive oxygen species antioxidants status is considered to be one of the causes of various pathological conditions of the reproductive system, including preeclampsia. The main objective of this study is to determine the activities of superoxide-dismutase and catalase in peripheral blood erythrocytes of the pregnant women with preeclampsia and healthy pregnant women before delivery and umbilical cord blood erythrocytes of their babies immediately after the delivery. The results showed that the activity of superoxide dismutase in erythrocytes were statistically significantly lower in the group of patients with preeclampsia than in healthy pregnant women, as in the group of their babies compared to the babies of healthy pregnant women. Similarly, catalase activity was significantly lower in women with preeclampsia compared to the controls, as well as in erythrocytes of their babies compared to babies of healthy mothers. An observed difference in the antioxidant enzyme activities suggests a putative association between preeclampsia and decreased antioxidant status. Since the direct application of antioxidants did not give expected results of the data presented indicate the opportunity for the prevention of preeclampsia and alleviation of symptoms by dietary measures and life style changes in the population of pregnant women and women of childbearing age, directy targeting the enzymatic antioxidant system.

Sposobnost organizma da zaustavi krvarenje iz oštećenog krvnog suda je neophoda za preživljavanje pacijenta.Isto tako,veliki uticaj ima i sposobnost organizma u regulisanju različitih procesa u koagulaciji krvi,čime
se može sprečiti nastanak tromboza i mogućih fatalnih posledica. U zdravom organizmu postoji ravnoteža
prokoagulantnih i antikoagulantnih faktora hemostaze i pod normalnim okolnostima sistem funkcioniše u korist prevage antikoagulacije Hirurške procedure u tretmanu bolesti ginekološkh organa nose veliki rizik za
nastanak dubokih venskih tromboza , imajući u vidu anatomske odnose u maloj karlici i bogatu vaskularizaciju obturatornih i ilijačnih jama.Standarna terapijska doza heparina niske molekulske mase (LMWH) sa ciljem prevencije nastanka venskih tromboza, a u slučajevima blagog i umerenog rizika je 3.000-5.000U/24
h.U svim slučajevima visokog rizika, doza niskomolekulskog heparina se može udvostručiti . Veća sklonost
ka nastanku dubokih venskih tromboza u svakoj hirurškoj proceduri u maloj karlici naročito kod ženske populacije, stavlja primenu heparina niske molekulske mase kao primarni cilj u prevenciji eventualne tromboembolijske bolesti.