During our perennial work with patients with systemic sclerosis we noticed that after the therapy of hyperbaric oxygenation (HBOt) they were able to their mouths open more easily. This treatment effect became visible when we started treating our patients with physical therapy. In order to find out whether this was patients’ subjective impression or an objective increase, we decided to keep the track of changes in mouth circumference before and after combined therapy of hyperbaric oxygenation and physical therapy. We treated the patients with ten HBO treatments at 2.0 ATA. Physical therapy lasted for ten days. First, the patients went to phototherapy with infrared rays (Solux lamp) for 15 minutes, at 40 cm intervals, perpendicularly, and then they went to kinesitherapy for mimic musculature in front of a mirror. Measurements before and after the therapy have shown a statistically significant difference and proved that the combination of HBO therapy and physical therapy has its place in treating these patients.