Increased number of patients with malignant disease as the cause of death requires a specific concept in the treatment and care those patients. The concept was launched in the UK today is important for patients in the terminal stage by a comprehensive approach to palliative care. Care for these patients is specific with regard of therapy, care and psychological support to patients and their family. Palliative care, effective and quality is reflected in the best possible provided techniques to improve the quality of life in patients in the terminal stage. Marked weakness, difficult movement or immobility, pains, nausea and vomiting, constipation, and decreased food intake of fluids, are just some problems which struggle patients, so that palliative care can be influenced to a greater conforms more dignified person. Patients in the terminal stage with the liver insufficiency and associated complications are the most complex with regard of palliative care. In this paper will demonstrate the principles of palliative care patients suffering from malignant disease in Gastroenterohepatology.