Diabetic foot syndrome represents one of the most severe complications of diabetes and is the leading cause of non-traumatic amputations. Wound healing is often impaired due to hypoxia, infection, and vascular changes. Hyperbaric oxygen therapy (HBOT) is used as an adjuvant method in the treatment of chronic wounds.

A 57-year-old patient is presented with a non-healing wound following amputation of the left foot due to gangrene associated with diabetic foot syndrome. After standard therapy and the introduction of HBOT (25 sessions at 2 ATA), a significant reduction in wound size and the development of granulation tissue were observed. Six months later, due to persistence of a smaller wound, an additional cycle of therapy was administered.

HBOT improves tissue oxygenation, stimulates angiogenesis, enhances the bactericidal activity of leukocytes, and accelerates tissue repair. When combined with standard treatment measures, it can significantly improve outcomes in patients with diabetic foot syndrome.

HBOT represents an effective adjuvant therapy in the treatment of chronic wounds in diabetic foot syndrome and may contribute to reducing the need for further amputations.