Introduction: Endometrial cancer is one of the most common malignant tumors of the female reproductive system. PCOS is a complex endocrinological disease of women of reproductive period.Conservative therapy implies a safe oncological outcome while preserving reproductive function.

Methods: This study is a cross-sectional clinical study conducted at Unirvesity Clinical Center of Serbia,Clinic for Gynecology and Obstetrics in the period from 2012 to 2024. The study included 62 patients who were between 23 and 45. The study included patients who were consecutively examined and treated conservatively for endometrial hyperplasia or endometrial cancer. Statistical analysis included methods of descriptive and analytical statistics.

Results: The results obtained in our study indicate that by evaluating the endocrinological status in patients with endometrial cancer, appropriate hygienic and dietary regimen, application of conservative therapy as well as psychosocial support to the patient. It is possible to obtain good therapeutic outcomes while preserving fertility in patients with endometrial cancer.

Conclusion: This study highlights the importance of alternative conservative treatment for endometrial cancer, especially in younger women with well-differentiated, early-stage endometrioid cancer

Prolonged endotracheal intubation in intensive care units (ICUs) is a frequent and clinically challenging aspect of managing critically ill patients. While intubation is essential for airway protection and adequate ventilation, its extended use is associated with a substantial risk of complications, including laryngeal and tracheal injury, ventilator-associated pneumonia, increased sedation requirements, prolonged mechanical ventilation, longer ICU stays, and higher mortality. In this setting, tracheotomy represents an important therapeutic alternative for patients anticipated to require long-term respiratory support.

This paper aims to examine the challenges of prolonged intubation, outline its most common complications, and explore the issue of optimal timing for tracheotomy. Particular attention is given to the comparison between early and late tracheotomy and their impact on key clinical outcomes, such as duration of mechanical ventilation, infection rates, patient comfort, sedation needs, and overall length of hospitalization. Evidence from the literature indicates that timely consideration of tracheotomy, combined with an individualized approach based on the patient’s clinical status and prognosis of the underlying condition, may reduce complication rates, facilitate ventilator weaning, and improve overall outcomes.

Furthermore, decision-making regarding tracheotomy is influenced by several factors, including the primary diagnosis, neurological status, expected duration of ventilatory support, and the risk of extubation failure. Modern clinical practice emphasizes the use of structured weaning protocols and close multidisciplinary collaboration among intensivists, anesthesiologists, otorhinolaryngologists, and nursing staff. This coordinated approach supports early identification of appropriate candidates for tracheotomy, reduces variability in clinical practice, and enhances patient safety.

In conclusion, determining the timing of tracheotomy requires careful assessment of risks and benefits within a multidisciplinary framework. Although no universally optimal time point exists, early recognition of patients likely to need prolonged mechanical ventilation and timely intervention may provide significant clinical benefits in contemporary intensive care medicine.