The role of elevated C-Reactive Protein (CRP) serum levels has been questioned in gestational diabetes mellitus (GDM) because of the evidences that metabolic syndrome and GDM are related to increased serum levels of inflammation markers (such as CRP). The aim of the study was to evaluate the sensitivity of elevated CRP levels for diagnosis of chorioamnionitis and to compare it with sensitivity of other standard laboratory or clinical signs used in the establishing of diagnosis of chorioamnionitis. Elevated CRP level was present in 93,33% cases. Fetal tachycardia was present in 91,67% cases. Increased white blood cell count was present in 63,33%. A statistically significant difference was found in the level of sensitivity of CRP and of the increased white blood cell count (P<0.01). Elevated C-reactive protein levels were more sensitive than other standard laboratory or clinical signs in predicting chorioamnionitis in women with GDM.